| Literature DB >> 28889261 |
Roberto Lucchini1,2, Donatella Placidi3, Giuseppa Cagna3, Chiara Fedrighi3, Manuela Oppini3, Marco Peli3, Silvia Zoni3.
Abstract
Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and executive functions through the involvement of the frontal cortex.Neurodevelopmental disturbances are increasing in the society, and understanding the potential role of environmental determinants is a key for prevention. Therefore, assessing the environmental sources of Mn exposure and the mechanisms of developmental neurotoxicity and defining appropriate biomarkers of exposure and early functional alterations represent key issues to improve and address preventive strategies. These themes will be reviewed in this chapter.Entities:
Keywords: Basal ganglia; Deposited dust; Fungicides; Methylcyclopentadienyl Mn tricarbonyl (MMT); Olfactory loss; Revised Conners’ Teacher Rating Scale; Vehicle emissions; Wechsler Intelligence Scale for Children (WISC)
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Year: 2017 PMID： 28889261 PMCID： PMC6057616 DOI： 10.1007/978-3-319-60189-2_2
Source DB: PubMed Journal: Adv Neurobiol