Literature DB >> 2157700

A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence.

P Blier1, C de Montigny, Y Chaput.   

Abstract

The electrophysiologic assessment of the action of different types of antidepressant treatments on the serotonin (5-hydroxytryptamine [5-HT]) system revealed as a common effect an enhancement of 5-HT neurotransmission, albeit each treatment achieved this result via a different mechanism. Tricyclic antidepressant drugs and electroconvulsive shock treatment sensitize postsynaptic neurons to 5-HT. Monoamine oxidase inhibitors enhance the availability of releasable 5-HT. Serotonin reuptake blockers increase the efficacy of 5-HT neurons by desensitizing 5-HT autoreceptors located on 5-HT nerve terminals. Serotonin1A receptor agonists would enhance the tonic activation of postsynaptic 5-HT1A receptors. Such results suggest that this effect of antidepressant treatments on the 5-HT system might be intimately related to their therapeutic effect in major depression.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2157700

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  49 in total

Review 1.  Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review.

Authors:  G B Baker; R T Coutts; K F McKenna; R L Sherry-McKenna
Journal:  J Psychiatry Neurosci       Date:  1992-11       Impact factor: 6.186

2.  Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons.

Authors:  Y Yao; P J Bergold; N J Penington
Journal:  Neuroscience       Date:  2010-04-25       Impact factor: 3.590

3.  Effects of milnacipran in animal models of anxiety and memory.

Authors:  Vânia K M Moojen; Márcio Rodrigo Martins; Adalisa Reinke; Gustavo Feier; Fabiano R Agostinho; Edson M Cechin; João Quevedo
Journal:  Neurochem Res       Date:  2006-05-09       Impact factor: 3.996

Review 4.  The serotonin1A receptor: a representative member of the serotonin receptor family.

Authors:  Thomas J Pucadyil; Shanti Kalipatnapu; Amitabha Chattopadhyay
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

5.  Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study.

Authors:  Shu Hasegawa; Arata Watanabe; Khanh Q Nguyen; Guy Debonnel; Mirko Diksic
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

Review 6.  The use of diet and dietary components in the study of factors controlling affect in humans: a review.

Authors:  S N Young
Journal:  J Psychiatry Neurosci       Date:  1993-11       Impact factor: 6.186

7.  Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats.

Authors:  Khanh Q Nguyen; Yoshihiro Tohyama; Arata Watanabe; Shu Hasegawa; Ivan Skelin; Mirko Diksic
Journal:  Neurochem Int       Date:  2008-11-27       Impact factor: 3.921

8.  Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

Authors:  Eric J Peters; Susan L Slager; Greg D Jenkins; Megan S Reinalda; Holly A Garriock; Stanley I Shyn; Jeffrey B Kraft; Patrick J McGrath; Steven P Hamilton
Journal:  Pharmacogenet Genomics       Date:  2009-01       Impact factor: 2.089

Review 9.  Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.

Authors:  Benjamin Adam Samuels; Indira Mendez-David; Charlène Faye; Sylvain André David; Kerri A Pierz; Alain M Gardier; René Hen; Denis J David
Journal:  Neuroscientist       Date:  2014-12-08       Impact factor: 7.519

10.  Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat.

Authors:  L J Boothman; K A Allers; K Rasmussen; T Sharp
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.