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Literature DB >> 23539597

Epigenetic reprogramming in cancer.

Mario L Suvà¹, Nicolo Riggi, Bradley E Bernstein.

Abstract

The demonstration of induced pluripotency and direct lineage conversion has led to remarkable insights regarding the roles of transcription factors and chromatin regulators in mediating cell state transitions. Beyond its considerable implications for regenerative medicine, this body of work is highly relevant to multiple stages of oncogenesis, from the initial cellular transformation to the hierarchical organization of established malignancies. Here, we review conceptual parallels between the respective biological phenomena, highlighting important interrelationships among transcription factors, chromatin regulators, and preexisting epigenetic states. The shared mechanisms provide insights into oncogenic transformation, tumor heterogeneity, and cancer stem cell models.

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Year: 2013 PMID： 23539597 PMCID： PMC3821556 DOI： 10.1126/science.1230184

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

64 in total

1. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53.

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Journal: EMBO J Date: 2010-06-25 Impact factor: 11.598

2. Lin28: A microRNA regulator with a macro role.

Authors: Srinivas R Viswanathan; George Q Daley
Journal: Cell Date: 2010-02-19 Impact factor: 41.582

3. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.

Authors: Jiekai Chen; He Liu; Jing Liu; Jing Qi; Bei Wei; Jiaqi Yang; Hanquan Liang; You Chen; Jing Chen; Yaran Wu; Lin Guo; Jieying Zhu; Xiangjie Zhao; Tianran Peng; Yixin Zhang; Shen Chen; Xuejia Li; Dongwei Li; Tao Wang; Duanqing Pei
Journal: Nat Genet Date: 2012-12-02 Impact factor: 38.330

Review 4. A blueprint for engineering cell fate: current technologies to reprogram cell identity.

Authors: Samantha A Morris; George Q Daley
Journal: Cell Res Date: 2013-01-01 Impact factor: 25.617

5. Transcriptional amplification in tumor cells with elevated c-Myc.

Authors: Charles Y Lin; Jakob Lovén; Peter B Rahl; Ronald M Paranal; Christopher B Burge; James E Bradner; Tong Ihn Lee; Richard A Young
Journal: Cell Date: 2012-09-28 Impact factor: 41.582

6. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Authors: Siân Jones; Tian-Li Wang; Ie-Ming Shih; Tsui-Lien Mao; Kentaro Nakayama; Richard Roden; Ruth Glas; Dennis Slamon; Luis A Diaz; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Journal: Science Date: 2010-09-08 Impact factor: 47.728

7. DNMT3A mutations in acute myeloid leukemia.

Authors: Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal: N Engl J Med Date: 2010-11-10 Impact factor: 91.245

8. Genome-wide chromatin state transitions associated with developmental and environmental cues.

Authors: Jiang Zhu; Mazhar Adli; James Y Zou; Griet Verstappen; Michael Coyne; Xiaolan Zhang; Timothy Durham; Mohammad Miri; Vikram Deshpande; Philip L De Jager; David A Bennett; Joseph A Houmard; Deborah M Muoio; Tamer T Onder; Ray Camahort; Chad A Cowan; Alexander Meissner; Charles B Epstein; Noam Shoresh; Bradley E Bernstein
Journal: Cell Date: 2013-01-17 Impact factor: 41.582

9. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Authors: Abed AlFatah Mansour; Ohad Gafni; Leehee Weinberger; Asaf Zviran; Muneef Ayyash; Yoach Rais; Vladislav Krupalnik; Mirie Zerbib; Daniela Amann-Zalcenstein; Itay Maza; Shay Geula; Sergey Viukov; Liad Holtzman; Ariel Pribluda; Eli Canaani; Shirley Horn-Saban; Ido Amit; Noa Novershtern; Jacob H Hanna
Journal: Nature Date: 2012-08-16 Impact factor: 49.962

10. Chromatin-modifying enzymes as modulators of reprogramming.

Authors: Tamer T Onder; Nergis Kara; Anne Cherry; Amit U Sinha; Nan Zhu; Kathrin M Bernt; Patrick Cahan; B Ogan Marcarci; Juli Unternaehrer; Piyush B Gupta; Eric S Lander; Scott A Armstrong; George Q Daley
Journal: Nature Date: 2012-03-04 Impact factor: 49.962

321 in total

1. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

Authors: Matthew T Holt; Yael David; Sam Pollock; Zhanyun Tang; Jongcheol Jeon; Jaehoon Kim; Robert G Roeder; Tom W Muir
Journal: Proc Natl Acad Sci U S A Date: 2015-08-03 Impact factor: 11.205

Review 2. An epigenetic gateway to brain tumor cell identity.

Authors: Stephen C Mack; Christopher G Hubert; Tyler E Miller; Michael D Taylor; Jeremy N Rich
Journal: Nat Neurosci Date: 2016-01 Impact factor: 24.884

3. Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.

Authors: Victor S Gehling; John P McGrath; Martin Duplessis; Avinash Khanna; Francois Brucelle; Rishi G Vaswani; Alexandre Côté; Jacob Stuckey; Venita Watson; Richard T Cummings; Srividya Balasubramanian; Priyadarshini Iyer; Priyanka Sawant; Andrew C Good; Brian K Albrecht; Jean-Christophe Harmange; James E Audia; Steven F Bellon; Patrick Trojer; Julian R Levell
Journal: ACS Med Chem Lett Date: 2020-05-06 Impact factor: 4.345

4. Epigenetic aberrant methylation of tumor suppressor genes in small cell lung cancer.

Authors: Shuai Wang; Zhou Wang
Journal: J Thorac Dis Date: 2013-08 Impact factor: 2.895

Review 5. Epigenetic plasticity and the hallmarks of cancer.

Authors: William A Flavahan; Elizabeth Gaskell; Bradley E Bernstein
Journal: Science Date: 2017-07-21 Impact factor: 47.728

6. Demethylation of the human eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3.

Authors: Eunjin Lim; Marc E Rothenberg
Journal: J Immunol Date: 2013-12-09 Impact factor: 5.422

Review 7. SOX7: from a developmental regulator to an emerging tumor suppressor.

Authors: Daniel B Stovall; Paul Cao; Guangchao Sui
Journal: Histol Histopathol Date: 2013-11-29 Impact factor: 2.303

Review 8. Mechanisms underlying the formation of induced pluripotent stem cells.

Authors: Federico González; Danwei Huangfu
Journal: Wiley Interdiscip Rev Dev Biol Date: 2015-09-18 Impact factor: 5.814

9. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

Authors: Jean-Pierre Etchegaray; Lukas Chavez; Yun Huang; Kenneth N Ross; Jiho Choi; Barbara Martinez-Pastor; Ryan M Walsh; Cesar A Sommer; Matthias Lienhard; Adrianne Gladden; Sita Kugel; Dafne M Silberman; Sridhar Ramaswamy; Gustavo Mostoslavsky; Konrad Hochedlinger; Alon Goren; Anjana Rao; Raul Mostoslavsky
Journal: Nat Cell Biol Date: 2015-04-27 Impact factor: 28.824

10. Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells.

Authors: Jagrut Patel; Somesh Baranwal; Ian M Love; Nirmita J Patel; Steven R Grossman; Bhaumik B Patel
Journal: Cell Cycle Date: 2014 Impact factor: 4.534