OBJECTIVE: The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck. METHODS: We used a case-control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis. RESULTS: We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81-4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27-0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs. CONCLUSION: Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field.
OBJECTIVE: The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck. METHODS: We used a case-control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis. RESULTS: We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81-4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27-0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs. CONCLUSION: Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field.
Authors: Pedro T Pisa; Titilola M Pedro; Kathleen Kahn; Stephen M Tollman; John M Pettifor; Shane A Norris Journal: Nutrients Date: 2015-05-12 Impact factor: 5.717
Authors: Aurelie Moskal; Pedro T Pisa; Pietro Ferrari; Graham Byrnes; Heinz Freisling; Marie-Christine Boutron-Ruault; Claire Cadeau; Laura Nailler; Andrea Wendt; Tilman Kühn; Heiner Boeing; Brian Buijsse; Anne Tjønneland; Jytte Halkjær; Christina C Dahm; Stephanie E Chiuve; Jose R Quirós; Genevieve Buckland; Esther Molina-Montes; Pilar Amiano; José M Huerta Castaño; Aurelio Barricarte Gurrea; Kay-Tee Khaw; Marleen A Lentjes; Timothy J Key; Dora Romaguera; Anne-Claire Vergnaud; Antonia Trichopoulou; Christina Bamia; Philippos Orfanos; Domenico Palli; Valeria Pala; Rosario Tumino; Carlotta Sacerdote; Maria Santucci de Magistris; H Bas Bueno-de-Mesquita; Marga C Ocké; Joline W J Beulens; Ulrika Ericson; Isabel Drake; Lena M Nilsson; Anna Winkvist; Elisabete Weiderpass; Anette Hjartåker; Elio Riboli; Nadia Slimani Journal: PLoS One Date: 2014-06-05 Impact factor: 3.240