BACKGROUND:Dogs with immune-mediated thrombocytopenia (ITP) are at risk of hemorrhage when platelet count is <50,000/μL. Treatment with vincristine (VINC) or human intravenous immunoglobulin (hIVIG) decreases platelet recovery time compared with treatment with corticosteroids alone. OBJECTIVES: To compare the effect of hIVIG versus VINC on platelet recovery in dogs with ITP. METHODS: Prospective, randomized study. Twenty dogs with idiopathic ITP (platelet count <16,000/μL) were enrolled. All dogs were treated with corticosteroids. Dogs were randomly assigned to receive a single dose of hIVIG (0.5 g/kg) or VINC (0.02 mg/kg). Outcome measures were platelet recovery time, duration of hospitalization, and survival to discharge. RESULTS: There was no significant difference in age, sex, weight, or initial platelet count between dogs treated with hIVIG (n = 10) and dogs treated with VINC (n = 10). Median platelet recovery time for both groups was 2.5 days (P = .51). Median hospitalization time for all dogs that survived to discharge was 4 days and not different between groups (P = .29). Seven of 10 dogs in the hIVIG group and 10 of 10 in the VINC group survived to discharge. Survival analysis did not identify any significant difference between the groups at discharge, 6 months, and 1 year after entry into the study. No adverse effects were reported in either group. CONCLUSIONS AND CLINICAL IMPORTANCE: Vincristine should be the first-line adjunctive treatment for the acute management of canine ITP because of lower cost and ease of administration compared with human intravenous immunoglobulin (hIVIG).
RCT Entities:
BACKGROUND:Dogs with immune-mediated thrombocytopenia (ITP) are at risk of hemorrhage when platelet count is <50,000/μL. Treatment with vincristine (VINC) or human intravenous immunoglobulin (hIVIG) decreases platelet recovery time compared with treatment with corticosteroids alone. OBJECTIVES: To compare the effect of hIVIG versus VINC on platelet recovery in dogs with ITP. METHODS: Prospective, randomized study. Twenty dogs with idiopathic ITP (platelet count <16,000/μL) were enrolled. All dogs were treated with corticosteroids. Dogs were randomly assigned to receive a single dose of hIVIG (0.5 g/kg) or VINC (0.02 mg/kg). Outcome measures were platelet recovery time, duration of hospitalization, and survival to discharge. RESULTS: There was no significant difference in age, sex, weight, or initial platelet count between dogs treated with hIVIG (n = 10) and dogs treated with VINC (n = 10). Median platelet recovery time for both groups was 2.5 days (P = .51). Median hospitalization time for all dogs that survived to discharge was 4 days and not different between groups (P = .29). Seven of 10 dogs in the hIVIG group and 10 of 10 in the VINC group survived to discharge. Survival analysis did not identify any significant difference between the groups at discharge, 6 months, and 1 year after entry into the study. No adverse effects were reported in either group. CONCLUSIONS AND CLINICAL IMPORTANCE: Vincristine should be the first-line adjunctive treatment for the acute management of canineITP because of lower cost and ease of administration compared with human intravenous immunoglobulin (hIVIG).
Authors: Kelly M Makielski; Marjory B Brooks; Chong Wang; Jonah N Cullen; Annette M O'Connor; Dana N LeVine Journal: J Vet Intern Med Date: 2018-04-21 Impact factor: 3.333
Authors: Jason P Bestwick; Mellora Sharman; Nat T Whitley; Caroline Kisielewicz; Barbara J Skelly; Simon Tappin; Lindsay Kellett-Gregory; Mayank Seth Journal: J Vet Intern Med Date: 2021-11-15 Impact factor: 3.333
Authors: Robert Goggs; Benjamin M Brainard; Dana N LeVine; Janine Calabro; Karyn Harrell; Tracy Mills; Richard Stone; Benjamin Davidson; Christine Iacovetta; Lauren Harris; John Gicking; Mary Aslanian; Ashley Ziegler; Brenda Fulcher; Teresa Lightfoot; Meredith Miller; John Loftus; Rebecca Walton; April Blong; Jennifer Kishbaugh; Anne S Hale Journal: J Vet Intern Med Date: 2020-10-05 Impact factor: 3.333