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Literature DB >> 23525668

ImmTACs: Novel bi-specific agents for targeted cancer therapy.

Joanne Oates¹, Bent K Jakobsen.
1. Immunocore Ltd; Abingdon, UK.

Abstract

Our expanding knowledge of the immune system is guiding a new era of targeted anticancer therapies. Here, we describe our recent work on a novel class of anticancer agents termed ImmTACs. These molecules combine the power of picomolar-affinity TCR-based antigen recognition with the immune-activating potential of an anti-CD3 antibody fragment, to potently redirect T-cell killing to tumor cells.

Entities: Chemical Disease Gene Species

Keywords: CD3; ImmTAC; T cell receptor; immunotherapy; thymic selection

Year: 2013 PMID： 23525668 PMCID： PMC3601161 DOI： 10.4161/onci.22891

Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110

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4. Directed evolution of human T-cell receptors with picomolar affinities by phage display.

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3. A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.

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