OBJECTIVES: Formal guidelines recommend that therapeutic hypothermia be considered after in-hospital cardiac arrest. The rate of therapeutic hypothermia use after in-hospital cardiac arrest and details about its implementation are unknown. We aimed to determine the use of therapeutic hypothermia for adult in-hospital cardiac arrest, whether use has increased over time, and to identify factors associated with its use. DESIGN: Multicenter, prospective cohort study. SETTING: A total of 538 hospitals participating in the Get With the Guidelines-Resuscitation database (2003-2009). PATIENTS: A total of 67,498 patients who had return of spontaneous circulation after in-hospital cardiac arrest. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the initiation of therapeutic hypothermia. We measured the proportion of therapeutic hypothermia patients who achieved target temperature (32-34 °C) and were overcooled. Of 67,498 patients, therapeutic hypothermia was initiated in 1,367 patients (2.0%). The target temperature (32-34 °C) was not achieved in 44.3% of therapeutic hypothermia patients within 24 hours and 17.6% were overcooled. The use of therapeutic hypothermia increased from 0.7% in 2003 to 3.3% in 2009 (p < 0.001). We found that younger age (p < 0.001) and occurrence in a non-ICU location (p < 0.001), on a weekday (p = 0.005), and in a teaching hospital (p = 0.001) were associated with an increased likelihood of therapeutic hypothermia being initiated. CONCLUSIONS: After in-hospital cardiac arrest, therapeutic hypothermia was used rarely. Once initiated, the target temperature was commonly not achieved. The frequency of use increased over time but remained low. Factors associated with therapeutic hypothermia use included patient age, time and location of occurrence, and type of hospital.
OBJECTIVES: Formal guidelines recommend that therapeutic hypothermia be considered after in-hospital cardiac arrest. The rate of therapeutic hypothermia use after in-hospital cardiac arrest and details about its implementation are unknown. We aimed to determine the use of therapeutic hypothermia for adult in-hospital cardiac arrest, whether use has increased over time, and to identify factors associated with its use. DESIGN: Multicenter, prospective cohort study. SETTING: A total of 538 hospitals participating in the Get With the Guidelines-Resuscitation database (2003-2009). PATIENTS: A total of 67,498 patients who had return of spontaneous circulation after in-hospital cardiac arrest. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the initiation of therapeutic hypothermia. We measured the proportion of therapeutic hypothermiapatients who achieved target temperature (32-34 °C) and were overcooled. Of 67,498 patients, therapeutic hypothermia was initiated in 1,367 patients (2.0%). The target temperature (32-34 °C) was not achieved in 44.3% of therapeutic hypothermiapatients within 24 hours and 17.6% were overcooled. The use of therapeutic hypothermia increased from 0.7% in 2003 to 3.3% in 2009 (p < 0.001). We found that younger age (p < 0.001) and occurrence in a non-ICU location (p < 0.001), on a weekday (p = 0.005), and in a teaching hospital (p = 0.001) were associated with an increased likelihood of therapeutic hypothermia being initiated. CONCLUSIONS: After in-hospital cardiac arrest, therapeutic hypothermia was used rarely. Once initiated, the target temperature was commonly not achieved. The frequency of use increased over time but remained low. Factors associated with therapeutic hypothermia use included patient age, time and location of occurrence, and type of hospital.
Authors: Jing Li; Michael Fettiplace; Sy-Jou Chen; Benjamin Steinhorn; Zuohui Shao; Xiangdong Zhu; Changqing Li; Shaun Harty; Guy Weinberg; Terry L Vanden Hoek Journal: Crit Care Med Date: 2014-12 Impact factor: 7.598
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Authors: Talal Alnabelsi; Rahul Annabathula; Julie Shelton; Marc Paranzino; Sarah Price Faulkner; Matthew Cook; Adam J Dugan; Sethabhisha Nerusu; Susan S Smyth; Vedant A Gupta Journal: Resusc Plus Date: 2020-11-07