| Literature DB >> 23518344 |
David Largaespada1, Nancy Ratner.
Abstract
WNT/β-catenin signaling is critical to the development of many cancer types. A paper by Mo and colleagues in a recent issue of Cell shows that autocrine CXCL12/CXCR4 chemokine signaling activates β-catenin signaling in a rare peripheral nerve sarcoma. Together with the availability of small molecules targeting CXCR4, this finding suggests new avenues for cancer therapy.Entities:
Year: 2013 PMID: 23518344 PMCID: PMC3635484 DOI: 10.1016/j.ccr.2013.03.001
Source DB: PubMed Journal: Cancer Cell ISSN: 1535-6108 Impact factor: 31.743