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Literature DB >> 23516045

β-Sitosterol and flavonoids isolated from Bauhinia malabarica found during screening for Wnt signaling inhibitory activity.

Hyun Young Park¹, Kazufumi Toume, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi.

Abstract

Screening with a cell-based luciferase assay was conducted to identify bioactive natural products which inhibit Wnt signaling activity-guided separation of an MeOH extract of Bauhinia malabarica (Caesalpiniaceae) leaves yielded five compounds, which were identified as β-sitosterol (1), quercetin (2), 6,8-C-dimethyl kaempferol-3-O-rhamnopyranoside (3), hyperin (4), and 6,8-C-dimethyl kaempferol-3-methyl ether (5). The tested compounds 1, 3, and 5 exhibited Wnt signaling inhibitory activity, with IC50 values of 0.77, 0.74, and 16.6 μM, respectively.

Entities: Chemical Species

Mesh：

Substances：

Year: 2013 PMID： 23516045 DOI： 10.1007/s11418-013-0762-3

Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343

21 in total

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Journal: Int J Pharm Date: 2003-03-26 Impact factor: 5.875

5. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.

Authors: Chi Hoon Park; Joon Young Chang; Eun Ryeong Hahm; Seyeon Park; Hyun-Kyung Kim; Chul Hak Yang
Journal: Biochem Biophys Res Commun Date: 2005-03-04 Impact factor: 3.575

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Authors: G V De Ferrari; N C Inestrosa
Journal: Brain Res Brain Res Rev Date: 2000-08

7. Cellular mechanisms underlying Hyperin-induced relaxation of rat basilar artery.

Authors: Yi-Fei Fan; Zhi-Wu Chen; Yan Guo; Qi-Hai Wang; Biao Song
Journal: Fitoterapia Date: 2011-02-12 Impact factor: 2.882

8. Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells.

Authors: Samira Benyahia; Samir Benayache; Fadila Benayache; José Quintana; Matías López; Francisco León; Juan C Hernández; Francisco Estévez; Jaime Bermejo
Journal: J Nat Prod Date: 2004-04 Impact factor: 4.050

9. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].

Authors: Katayoon H Emami; Cu Nguyen; Hong Ma; Dae Hoon Kim; Kwang Won Jeong; Masakatsu Eguchi; Randall T Moon; Jia-Ling Teo; Se Woong Oh; Hak Yeop Kim; Sung Hwan Moon; Jong Ryul Ha; Michael Kahn
Journal: Proc Natl Acad Sci U S A Date: 2004-08-16 Impact factor: 11.205

4. Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Properties of Anthyllis henoniana (Coss.) Flowers Extracts in an Alloxan-Induced Rats Model of Diabetes.

Authors: Ameur Ben Younes; Maryem Ben Salem; Hanen El Abed; Raoudha Jarraya
Journal: Evid Based Complement Alternat Med Date: 2018-06-24 Impact factor: 2.629

4 in total