Literature DB >> 23512950

Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?

Martin Harrow1, Thomas H Jobe.   

Abstract

Antipsychotic medications are viewed as cornerstones for both the short-term and long-term treatment of schizophrenia. However, evidence on long-term (10 or more years) efficacy of antipsychotics is mixed. Double-blind discontinuation studies indicate significantly more relapses in unmedicated schizophrenia patients in the first 6-10 months, but also present some potentially paradoxical features. These issues are discussed.

Entities:  

Keywords:  longitudinal studies; outcome; psychosis; unmedicated patients

Mesh：

Substances：

Year:  2013        PMID： 23512950      PMCID： PMC3756791          DOI： 10.1093/schbul/sbt034

Source DB:  PubMed          Journal:  Schizophr Bull        ISSN： 0586-7614            Impact factor:   9.306


  25 in total

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Review 3.  Practice guideline for the treatment of patients with schizophrenia, second edition.

Authors:  Anthony F Lehman; Jeffrey A Lieberman; Lisa B Dixon; Thomas H McGlashan; Alexander L Miller; Diana O Perkins; Julie Kreyenbuhl
Journal:  Am J Psychiatry       Date:  2004-02       Impact factor: 18.112

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Authors:  Martin Harrow; Thomas H Jobe
Journal:  J Nerv Ment Dis       Date:  2007-05       Impact factor: 2.254

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Journal:  Schizophr Res       Date:  2008-02-19       Impact factor: 4.939

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Authors:  J Moncrieff
Journal:  Acta Psychiatr Scand       Date:  2006-07       Impact factor: 6.392

8.  Neuroleptic withdrawal in schizophrenic patients. A review of the literature.

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Journal:  Arch Gen Psychiatry       Date:  1995-03

9.  Do patients with schizophrenia ever show periods of recovery? A 15-year multi-follow-up study.

Authors:  Martin Harrow; Linda S Grossman; Thomas H Jobe; Ellen S Herbener
Journal:  Schizophr Bull       Date:  2005-07-14       Impact factor: 9.306

10.  What did the WHO studies really find?

Authors:  Assen Jablensky; Norman Sartorius
Journal:  Schizophr Bull       Date:  2008-01-18       Impact factor: 9.306
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  20 in total

1.  Declining Clinical Course of Psychotic Disorders Over the Two Decades Following First Hospitalization: Evidence From the Suffolk County Mental Health Project.

Authors:  Roman Kotov; Laura Fochtmann; Kaiqiao Li; Marsha Tanenberg-Karant; Eduardo A Constantino; Joan Rubinstein; Greg Perlman; Eva Velthorst; Anne-Kathrin J Fett; Gabrielle Carlson; Evelyn J Bromet
Journal:  Am J Psychiatry       Date:  2017-08-04       Impact factor: 18.112

2.  Successful management of clozapine adverse effects with extended (alternate day) antipsychotic dosing in a patient with schizophrenia.

Authors:  Vijaya Kumar; Lavanya Sharma; Srikanth Madival; Ganesan Venkatasubramanian
Journal:  J Psychiatry Neurosci       Date:  2016-01       Impact factor: 6.186

Review 3.  [Frontal brain volume reduction due to antipsychotic drugs?].

Authors:  V Aderhold; S Weinmann; C Hägele; A Heinz
Journal:  Nervenarzt       Date:  2015-03       Impact factor: 1.214

Review 4.  The Use of Continuous Treatment Versus Placebo or Intermittent Treatment Strategies in Stabilized Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with First- and Second-Generation Antipsychotics.

Authors:  Marc De Hert; Jan Sermon; Paul Geerts; Kristof Vansteelandt; Joseph Peuskens; Johan Detraux
Journal:  CNS Drugs       Date:  2015-08       Impact factor: 5.749

Review 5.  Antipsychotic dosing: found in translation.

Authors:  Gary Remington; Gagan Fervaha; George Foussias; Ofer Agid; Peter Turrone
Journal:  J Psychiatry Neurosci       Date:  2014-07       Impact factor: 6.186

6.  A 20-Year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia.

Authors:  Martin Harrow; Thomas H Jobe; Robert N Faull; Jie Yang
Journal:  Psychiatry Res       Date:  2017-06-22       Impact factor: 3.222

7.  Schizophrenia--time to commit to policy change.

Authors:  W Wolfgang Fleischhacker; Celso Arango; Paul Arteel; Thomas R E Barnes; William Carpenter; Ken Duckworth; Silvana Galderisi; Lisa Halpern; Martin Knapp; Stephen R Marder; Mary Moller; Norman Sartorius; Peter Woodruff
Journal:  Schizophr Bull       Date:  2014-04       Impact factor: 9.306

8.  Psychoeducation Improves Compliance and Outcome in Schizophrenia Without an Increase of Adverse Side Effects: A 7-Year Follow-up of the Munich PIP-Study.

Authors:  Josef Bäuml; Gabriele Pitschel-Walz; Anja Volz; Sandra Lüscher; Michael Rentrop; Werner Kissling; Thomas Jahn
Journal:  Schizophr Bull       Date:  2016-03-08       Impact factor: 9.306

Review 9.  Weighing the evidence for harm from long-term treatment with antipsychotic medications: A systematic review.

Authors:  Nancy Sohler; Ben G Adams; David M Barnes; Gregory H Cohen; Seth J Prins; Sharon Schwartz
Journal:  Am J Orthopsychiatry       Date:  2015-12-14

Review 10.  The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies.

Authors:  Chengmin Yang; Jing Tang; Naici Liu; Li Yao; Mengyuan Xu; Hui Sun; Bo Tao; Qiyong Gong; Hengyi Cao; Wenjing Zhang; Su Lui
Journal:  Front Psychiatry       Date:  2021-06-24       Impact factor: 4.157
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