Literature DB >> 23512552

Synthesis of novel isoquinolinone and 1,2-dihydroisoquinoline scaffolds via Ugi reaction and ring opening reaction of furans.

Fei Ji1, Wen-bin Yi, Mu Sun, Mei-fang Lv, Chun Cai.   

Abstract

Combining the Ugi reaction with ring opening reaction of furans for the synthesis of novel isoquinolinone and 1,2-dihydroisoquinoline scaffolds has been developed. The isoquinolinone and 1,2-dihydroisoquinoline derivatives with unsaturated carbonyl moiety may open up many opportunities for further functionalizations.

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Year:  2013        PMID： 23512552     DOI： 10.1007/s11030-013-9434-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  22 in total

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2.  Diphenyl quinolines and isoquinolines: synthesis and primary biological evaluation.

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Journal:  Bioorg Med Chem       Date:  2000-11       Impact factor: 3.641

3.  Aromaticity as a cornerstone of heterocyclic chemistry.

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4.  A novel entry to functionalized benzofurans and indoles via palladium(0)-catalyzed arylative dearomatization of furans.

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Journal:  Org Lett       Date:  2012-02-08       Impact factor: 6.005

5.  Gold-catalyzed furan/yne cyclizations for the regiodefined assembly of multisubstituted protected 1-naphthols.

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6.  Copper-free route to triazole-modified peptidomimetic by the combination of two multicomponent reactions in one pot.

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7.  A domino synthesis of benzoquinolinamide in the presence of iodine.

Authors:  Li-Yan Zeng; Chun Cai
Journal:  Org Biomol Chem       Date:  2010-09-06       Impact factor: 3.876

8.  Synthesis of 3,4-disubstituted isoquinolines via palladium-catalyzed cross-coupling of 2-(1-alkynyl)benzaldimines and organic halides.

Authors:  Guangxiu Dai; Richard C Larock
Journal:  J Org Chem       Date:  2003-02-07       Impact factor: 4.354

9.  Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

Authors:  G Kohlhagen; K D Paull; M Cushman; P Nagafuji; Y Pommier
Journal:  Mol Pharmacol       Date:  1998-07       Impact factor: 4.436

10.  Naphthalenes, isoquinolines, and a benzazocine from zirconocene-copper-mediated coupling of benzocyclobutadiene with nitriles and alkynes.

Authors:  T V V Ramakrishna; Paul R Sharp
Journal:  Org Lett       Date:  2003-03-20       Impact factor: 6.005
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  1 in total

1.  Synthesis of dihydroisoquinolinone-4-methylboronic esters via domino Heck/borylation using a structurally characterized palladacycle as a catalyst.

Authors:  Jhansi Rani Morla; Dastagiri Reddy Nareddula
Journal:  RSC Adv       Date:  2022-02-28       Impact factor: 3.361
  1 in total

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