Cindy Huang1, Sue A Shapses, Xiangbing Wang. 1. Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Abstract
OBJECTIVE: To review the current literature investigating the association of plasma parathyroid hormone (PTH) with the prevalence of metabolic syndrome and the risk for cardiovascular disease (CVD). METHODS: We conducted a search of PubMed and Medline database using the terms hyperparathyroidism, metabolic syndrome, hypertension, hyperlipidemia, hyperglycemia, and CVD. We reviewed relevant studies from 2004 to 2012. RESULTS: The current literature assessing the association of plasma PTH levels with metabolic syndrome and CVD is inconsistent; however, positive associations among hyperparathyroidism, metabolic syndrome, and CVD were found in a majority of the studies. The differences in the study populations may partly explain the mixed results. CONCLUSION: In the general population, a high serum PTH level predisposes patients to CVD mortality. Further research is needed to determine the role of PTH in the etiology of metabolic syndrome and CVD.
OBJECTIVE: To review the current literature investigating the association of plasma parathyroid hormone (PTH) with the prevalence of metabolic syndrome and the risk for cardiovascular disease (CVD). METHODS: We conducted a search of PubMed and Medline database using the terms hyperparathyroidism, metabolic syndrome, hypertension, hyperlipidemia, hyperglycemia, and CVD. We reviewed relevant studies from 2004 to 2012. RESULTS: The current literature assessing the association of plasma PTH levels with metabolic syndrome and CVD is inconsistent; however, positive associations among hyperparathyroidism, metabolic syndrome, and CVD were found in a majority of the studies. The differences in the study populations may partly explain the mixed results. CONCLUSION: In the general population, a high serum PTH level predisposes patients to CVD mortality. Further research is needed to determine the role of PTH in the etiology of metabolic syndrome and CVD.
Authors: Paulette D Chandler; Foluso Agboola; Kimmie Ng; Jamil B Scott; Bettina F Drake; Gary G Bennett; Andrew T Chan; Bruce W Hollis; Karen M Emmons; Charles S Fuchs; Edward L Giovannucci Journal: BMC Nutr Date: 2015-12-17