Paulette D Chandler1, Foluso Agboola2, Kimmie Ng3, Jamil B Scott4, Bettina F Drake5, Gary G Bennett6, Andrew T Chan7, Bruce W Hollis8, Karen M Emmons9, Charles S Fuchs3, Edward L Giovannucci10. 1. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. 2. Division of Policy Translation and Leadership Development, Harvard School of Public Health, Boston, MA. 3. Harvard Medical School, Boston, MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. 4. Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI. 5. Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO. 6. Department of Psychology and Neuroscience, Duke University, Durham, NC. 7. Harvard Medical School, Boston, MA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA. 8. Division of Pediatrics, Medical University of South Carolina, Charleston, SC. 9. Harvard Medical School, Boston, MA; Center for Community-Based Research, Dana-Farber Cancer Institute, Boston, MA. 10. Harvard Medical School, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, BostoN; Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA.
Abstract
BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. METHODS:During 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. RESULTS: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d ( -2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p<0.001). CONCLUSION: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Clinical Trials.gov: NCT00585637.
RCT Entities:
BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. METHODS: During 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. RESULTS: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d ( -2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p<0.001). CONCLUSION: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Clinical Trials.gov: NCT00585637.
Entities:
Keywords:
Blacks; parathyroid hormone; supplementation; vitamin D
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