| Literature DB >> 23506871 |
Juan Pablo Arroyo1, Kristopher T Kahle, Gerardo Gamba.
Abstract
The SLC12 family encodes electroneutral cation-coupled chloride cotransporters that are critical for several physiological processes including cell volume regulation, modulation of intraneuronal chloride concentration, transepithelial ion movement, and blood pressure regulation. Members of this family are the targets of the most commonly used diuretic drugs, have been shown to be the causative genes for inherited disease such as Gitelman, Bartter and Andermann syndromes, and potentially play a role in polygenic complex diseases like arterial hypertension, epilepsy, osteoporosis, and cancer.Entities:
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Year: 2013 PMID： 23506871 DOI： 10.1016/j.mam.2012.05.002
Source DB: PubMed Journal: Mol Aspects Med ISSN： 0098-2997