Literature DB >> 23506868

SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.

Mark Donowitz1, C Ming Tse, Daniel Fuster.   

Abstract

This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23506868      PMCID： PMC3724465          DOI： 10.1016/j.mam.2012.05.001

Source DB:  PubMed          Journal:  Mol Aspects Med        ISSN： 0098-2997


  113 in total

Review 1.  Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.

Authors:  Ryuichi Ohgaki; Sven C D van IJzendoorn; Masafumi Matsushita; Dick Hoekstra; Hiroshi Kanazawa
Journal:  Biochemistry       Date:  2010-12-30       Impact factor: 3.162

2.  Immunolocalization of NHE8 in rat kidney.

Authors:  Sunita Goyal; SueAnn Mentone; Peter S Aronson
Journal:  Am J Physiol Renal Physiol       Date:  2004-11-02

3.  beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.

Authors:  Elöd Z Szabó; Masayuki Numata; Viktoria Lukashova; Pietro Iannuzzi; John Orlowski
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-07       Impact factor: 11.205

4.  Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.

Authors:  Youssef Ben Ammar; Soichi Takeda; Takashi Hisamitsu; Hidezo Mori; Shigeo Wakabayashi
Journal:  EMBO J       Date:  2006-05-18       Impact factor: 11.598

5.  Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.

Authors:  Willy Hofstetter; Mark Siegrist; Alexandre Simonin; Olivier Bonny; Daniel G Fuster
Journal:  Bone       Date:  2010-05-11       Impact factor: 4.398

6.  CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.

Authors:  Viktoria Lukashova; Elöd Z Szabó; Tushare Jinadasa; Alexei Mokhov; David W Litchfield; John Orlowski
Journal:  J Biol Chem       Date:  2011-02-04       Impact factor: 5.157

7.  Impact of sodium/proton exchanger 3 gene variants on sudden infant death syndrome.

Authors:  Micaela Poetsch; Bente J Nottebaum; Lisa Wingenfeld; Stilla Frede; Mechtild Vennemann; Thomas Bajanowski
Journal:  J Pediatr       Date:  2010-01       Impact factor: 4.406

8.  IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium.

Authors:  Peijian He; Huanchun Zhang; C Chris Yun
Journal:  J Biol Chem       Date:  2008-09-30       Impact factor: 5.157

9.  Identifying autism loci and genes by tracing recent shared ancestry.

Authors:  Eric M Morrow; Seung-Yun Yoo; Steven W Flavell; Tae-Kyung Kim; Yingxi Lin; Robert Sean Hill; Nahit M Mukaddes; Soher Balkhy; Generoso Gascon; Asif Hashmi; Samira Al-Saad; Janice Ware; Robert M Joseph; Rachel Greenblatt; Danielle Gleason; Julia A Ertelt; Kira A Apse; Adria Bodell; Jennifer N Partlow; Brenda Barry; Hui Yao; Kyriacos Markianos; Russell J Ferland; Michael E Greenberg; Christopher A Walsh
Journal:  Science       Date:  2008-07-11       Impact factor: 47.728

10.  A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility.

Authors:  Dan Wang; Shelby M King; Timothy A Quill; Lynda K Doolittle; David L Garbers
Journal:  Nat Cell Biol       Date:  2003-11-23       Impact factor: 28.824
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  102 in total

1.  Towards bridging the gap between acid-base transporters and neuronal excitability modulation.

Authors:  Ying Liu; Li-Ming Chen
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2014-12-15

2.  Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse.

Authors:  Ali Shawki; Melinda A Engevik; Robert S Kim; Patrick B Knight; Rusty A Baik; Sarah R Anthony; Roger T Worrell; Gary E Shull; Bryan Mackenzie
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2016-07-07       Impact factor: 4.052

3.  The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3.

Authors:  Victor Babich; Komal Vadnagara; Francesca Di Sole
Journal:  FASEB J       Date:  2013-08-09       Impact factor: 5.191

4.  Role of Cl- -HCO3- exchanger AE3 in intracellular pH homeostasis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes.

Authors:  Ahlam I Salameh; Christian A Hübner; Walter F Boron
Journal:  J Physiol       Date:  2016-11-06       Impact factor: 5.182

5.  Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3.

Authors:  Devishree Krishnan; Lei Liu; Shane A Wiebe; Joseph R Casey; Emmanuelle Cordat; R Todd Alexander
Journal:  Am J Physiol Renal Physiol       Date:  2015-06-03

6.  Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.

Authors:  Boyoung Cha; Tiane Chen; Rafiquel Sarker; Jianbo Yang; Daniel Raben; C Ming Tse; Olga Kovbasnjuk; Mark Donowitz
Journal:  Am J Physiol Cell Physiol       Date:  2014-04-23       Impact factor: 4.249

7.  Na+/H+ and Na+/NH+4 activities of zebrafish NHE3b expressed in Xenopus oocytes.

Authors:  Yusuke Ito; Akira Kato; Taku Hirata; Shigehisa Hirose; Michael F Romero
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2014-01-08       Impact factor: 3.619

8.  Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene.

Authors:  Roger S Holmes; Kimberly D Spradling-Reeves; Laura A Cox
Journal:  J Phylogenetics Evol Biol       Date:  2016-06-10

9.  Sodium-Hydrogen-Exchanger expression in human sperm and its relationship with semen parameters.

Authors:  Zhe Zhang; Yuzhuo Yang; Han Wu; Hongliang Zhang; Haitao Zhang; Jiaming Mao; Defeng Liu; Lianming Zhao; Haocheng Lin; Wenhao Tang; Kai Hong; Hui Jiang
Journal:  J Assist Reprod Genet       Date:  2017-04-21       Impact factor: 3.412

10.  Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1.

Authors:  Simon Fuchs; Sierra C Hansen; Marie Markones; Evgeny V Mymrikov; Heiko Heerklotz; Carola Hunte
Journal:  Sci Rep       Date:  2018-10-04       Impact factor: 4.379
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