Literature DB >> 23505633

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.

Wolfgang Kandioller1, Evelyn Balsano, Samuel M Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A Jakupec, Walter Berger, Bernhard K Keppler, Christian G Hartinger.   

Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

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Year:  2013        PMID： 23505633     DOI： 10.1039/c3cc40432c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents.

Authors:  Narasinga Rao Palepu; S L Nongbri; J Richard Premkumar; Akalesh Kumar Verma; Kaushik Bhattacharjee; S R Joshi; Scott Forbes; Yurij Mozharivskyj; Romita Thounaojam; K Aguan; Mohan Rao Kollipara
Journal:  J Biol Inorg Chem       Date:  2015-02-25       Impact factor: 3.358

Review 2.  Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies.

Authors:  Mehvash Zaki; Suboot Hairat; Elham S Aazam
Journal:  RSC Adv       Date:  2019-01-24       Impact factor: 4.036

3.  Understanding the interactions of diruthenium anticancer agents with amino acids.

Authors:  Alexey A Nazarov; Maria-Grazia Mendoza-Ferri; Muhammad Hanif; Bernhard K Keppler; Paul J Dyson; Christian G Hartinger
Journal:  J Biol Inorg Chem       Date:  2018-07-25       Impact factor: 3.358

4.  In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.

Authors:  Russell J Needham; Carlos Sanchez-Cano; Xin Zhang; Isolda Romero-Canelón; Abraha Habtemariam; Margaret S Cooper; Levente Meszaros; Guy J Clarkson; Philip J Blower; Peter J Sadler
Journal:  Angew Chem Int Ed Engl       Date:  2016-12-21       Impact factor: 15.336

5.  Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide.

Authors:  Jahanzaib Arshad; Kelvin K H Tong; Sanam Movassaghi; Tilo Söhnel; Stephen M F Jamieson; Muhammad Hanif; Christian G Hartinger
Journal:  Molecules       Date:  2021-02-05       Impact factor: 4.411

6.  Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies.

Authors:  Heiko Geisler; Julia Westermayr; Klaudia Cseh; Dominik Wenisch; Valentin Fuchs; Sophia Harringer; Sarah Plutzar; Natalie Gajic; Michaela Hejl; Michael A Jakupec; Philipp Marquetand; Wolfgang Kandioller
Journal:  Inorg Chem       Date:  2021-06-11       Impact factor: 5.165

7.  A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells.

Authors:  Rone A De Grandis; Katia M Oliveira; Adriana P M Guedes; Patrick W S Dos Santos; Alexandre F Aissa; Alzir A Batista; Fernando R Pavan
Journal:  Front Oncol       Date:  2021-06-24       Impact factor: 6.244

8.  Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy.

Authors:  Divyashree Ravishankar; Maryam Salamah; Alda Attina; Radhika Pothi; Thomas M Vallance; Muhammad Javed; Harry F Williams; Eman M S Alzahrani; Elena Kabova; Rajendran Vaiyapuri; Kenneth Shankland; Jonathan Gibbins; Katja Strohfeldt; Francesca Greco; Helen M I Osborn; Sakthivel Vaiyapuri
Journal:  Sci Rep       Date:  2017-07-18       Impact factor: 4.379

9.  Crystal structure of bromido(η6-1-isopropyl-4-methylbenzene)(7-oxocyclohepta-1,3,5-trien-1-olato-κ2O,O')osmium.

Authors:  Hadley S Clayton; Kgaugelo C Tapala; Andreas Lemmerer
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-02-02

10.  Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.

Authors:  István Kacsir; Adrienn Sipos; Attila Bényei; Eszter Janka; Péter Buglyó; László Somsák; Péter Bai; Éva Bokor
Journal:  Int J Mol Sci       Date:  2022-01-12       Impact factor: 5.923
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