Literature DB >> 23505632

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide.

Jeffrey R Brender1, Janarthanan Krishnamoorthy, Grazia M L Messina, Aniruddha Deb, Subramanian Vivekanandan, Carmelo La Rosa, James E Penner-Hahn, Ayyalusamy Ramamoorthy.   

Abstract

The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.

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Year:  2013        PMID： 23505632     DOI： 10.1039/c3cc40383a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

Review 1.  Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.

Authors:  Akira Naito; Nobuaki Matsumori; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-06-06       Impact factor: 3.770

2.  Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.

Authors:  Young-Ho Lee; Yuxi Lin; Sarah J Cox; Misaki Kinoshita; Bikash R Sahoo; Magdalena Ivanova; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2018-11-22       Impact factor: 3.036

3.  Regulation of the aggregation behavior of human islet amyloid polypeptide fragment by titanocene complexes.

Authors:  Weihong Du; Gehui Gong; Wenji Wang; Jufei Xu
Journal:  J Biol Inorg Chem       Date:  2017-08-11       Impact factor: 3.358

Review 4.  Membrane-mediated amyloid deposition of human islet amyloid polypeptide.

Authors:  Kenji Sasahara
Journal:  Biophys Rev       Date:  2017-12-04

5.  Heterotropic Modulation of Amylin Fibrillation by Small Molecules: Implications for Formulative Designs.

Authors:  Celimar Sinézia; Luís Maurício T R Lima
Journal:  Protein J       Date:  2020-02       Impact factor: 2.371

6.  Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.

Authors:  Abhinav Nath; Diana E Schlamadinger; Elizabeth Rhoades; Andrew D Miranker
Journal:  Biochemistry       Date:  2015-05-22       Impact factor: 3.162

7.  Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.

Authors:  Xinwei Ge; Aleksandr Kakinen; Esteban N Gurzov; Wen Yang; Lokman Pang; Emily H Pilkington; Praveen Govindan-Nedumpully; Pengyu Chen; Frances Separovic; Thomas P Davis; Pu Chun Ke; Feng Ding
Journal:  Chem Commun (Camb)       Date:  2017-08-22       Impact factor: 6.222

8.  Influence of methionine-ruthenium complex on the fibril formation of human islet amyloid polypeptide.

Authors:  Gehui Gong; Jufei Xu; Xiangyi Huang; Weihong Du
Journal:  J Biol Inorg Chem       Date:  2019-01-30       Impact factor: 3.358

9.  Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: MECHANISTIC DETAILS STUDIED BY SPECTROSCOPY IN COMBINATION WITH MICROSCOPY.

Authors:  Bhisma N Ratha; Anirban Ghosh; Jeffrey R Brender; Nilanjan Gayen; Humaira Ilyas; Chilukoti Neeraja; Kali P Das; Atin K Mandal; Anirban Bhunia
Journal:  J Biol Chem       Date:  2016-09-27       Impact factor: 5.157

Review 10.  Recent advances in the molecular genetics of type 2 diabetes mellitus.

Authors:  Antonio Brunetti; Eusebio Chiefari; Daniela Foti
Journal:  World J Diabetes       Date:  2014-04-15
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