Literature DB >> 28745731

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.

Xinwei Ge1, Aleksandr Kakinen, Esteban N Gurzov, Wen Yang, Lokman Pang, Emily H Pilkington, Praveen Govindan-Nedumpully, Pengyu Chen, Frances Separovic, Thomas P Davis, Pu Chun Ke, Feng Ding.   

Abstract

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.

Entities:  

Year:  2017        PMID： 28745731      PMCID： PMC5570498          DOI： 10.1039/c7cc04291d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  30 in total

1.  The mechanism of insulin action on islet amyloid polypeptide fiber formation.

Authors:  Jennifer L Larson; Andrew D Miranker
Journal:  J Mol Biol       Date:  2004-01-02       Impact factor: 5.469

Review 2.  ZnT-8, a pancreatic beta-cell-specific zinc transporter.

Authors:  Fabrice Chimienti; Alain Favier; Michel Seve
Journal:  Biometals       Date:  2005-08       Impact factor: 2.949

3.  Molecular mapping of the recognition interface between the islet amyloid polypeptide and insulin.

Authors:  Sharon Gilead; Haguy Wolfenson; Ehud Gazit
Journal:  Angew Chem Int Ed Engl       Date:  2006-10-06       Impact factor: 15.336

4.  Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

Authors:  Robert A Ritzel; Juris J Meier; Chia-Yu Lin; Johannes D Veldhuis; Peter C Butler
Journal:  Diabetes       Date:  2007-01       Impact factor: 9.461

5.  The role of His-18 in amyloid formation by human islet amyloid polypeptide.

Authors:  Andisheh Abedini; Daniel P Raleigh
Journal:  Biochemistry       Date:  2005-12-13       Impact factor: 3.162

Review 6.  Role of C-peptide in human physiology.

Authors:  J Wahren; K Ekberg; J Johansson; M Henriksson; A Pramanik; B L Johansson; R Rigler; H Jörnvall
Journal:  Am J Physiol Endocrinol Metab       Date:  2000-05       Impact factor: 4.310

Review 7.  Amylin agonists: a novel approach in the treatment of diabetes.

Authors:  Ole Schmitz; Birgitte Brock; Jorgen Rungby
Journal:  Diabetes       Date:  2004-12       Impact factor: 9.461

8.  Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

Authors:  K Lemaire; M A Ravier; A Schraenen; J W M Creemers; R Van de Plas; M Granvik; L Van Lommel; E Waelkens; F Chimienti; G A Rutter; P Gilon; P A in't Veld; F C Schuit
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-18       Impact factor: 11.205

9.  Mass spectrometric characterization and activity of zinc-activated proinsulin C-peptide and C-peptide mutants.

Authors:  Zachary Keltner; Jennifer A Meyer; Erin M Johnson; Amanda M Palumbo; Dana M Spence; Gavin E Reid
Journal:  Analyst       Date:  2009-12-04       Impact factor: 4.616

10.  Ab initio folding of proteins with all-atom discrete molecular dynamics.

Authors:  Feng Ding; Douglas Tsao; Huifen Nie; Nikolay V Dokholyan
Journal:  Structure       Date:  2008-07       Impact factor: 5.006
View more
  8 in total

1.  Graphene quantum dots against human IAPP aggregation and toxicity in vivo.

Authors:  Miaoyi Wang; Yunxiang Sun; Xueying Cao; Guotao Peng; Ibrahim Javed; Aleksandr Kakinen; Thomas P Davis; Sijie Lin; Jingquan Liu; Feng Ding; Pu Chun Ke
Journal:  Nanoscale       Date:  2018-11-01       Impact factor: 7.790

2.  Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.

Authors:  Yanting Xing; Emily H Pilkington; Miaoyi Wang; Cameron J Nowell; Aleksandr Kakinen; Yunxiang Sun; Bo Wang; Thomas P Davis; Feng Ding; Pu Chun Ke
Journal:  Phys Chem Chem Phys       Date:  2017-11-22       Impact factor: 3.676

3.  Elucidation of a Copper Binding Site in Proinsulin C-peptide and Its Implications for Metal-Modulated Activity.

Authors:  Michael J Stevenson; Samuel E Janisse; Lizhi Tao; Ryan L Neil; Quang D Pham; R David Britt; Marie C Heffern
Journal:  Inorg Chem       Date:  2020-06-08       Impact factor: 5.165

4.  Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons.

Authors:  Ava Faridi; Yunxiang Sun; Yutaka Okazaki; Guotao Peng; Jie Gao; Aleksandr Kakinen; Pouya Faridi; Mei Zhao; Ibrahim Javed; Anthony W Purcell; Thomas P Davis; Sijie Lin; Reiko Oda; Feng Ding; Pu Chun Ke
Journal:  Small       Date:  2018-10-07       Impact factor: 13.281

5.  Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide.

Authors:  Emily H Pilkington; Ove J R Gustafsson; Yanting Xing; Juan Hernandez-Fernaud; Cleidi Zampronio; Aleksandr Kakinen; Ava Faridi; Feng Ding; Paul Wilson; Pu Chun Ke; Thomas P Davis
Journal:  ACS Nano       Date:  2018-05-16       Impact factor: 15.881

6.  Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance.

Authors:  Elena Atrián-Blasco; Paulina Gonzalez; Alice Santoro; Bruno Alies; Peter Faller; Christelle Hureau
Journal:  Coord Chem Rev       Date:  2018-09-15       Impact factor: 22.315

Review 7.  Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas.

Authors:  Diti Chatterjee Bhowmick; Zhanar Kudaibergenova; Lydia Burnett; Aleksandar M Jeremic
Journal:  Molecules       Date:  2022-02-02       Impact factor: 4.411

8.  α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine.

Authors:  Amber L H Gray; Aleksandra Antevska; Benjamin A Link; Bryan Bogin; Susan J Burke; Samuel D Dupuy; J Jason Collier; Zachary A Levine; Michael D Karlstad; Thanh D Do
Journal:  Chem Sci       Date:  2021-03-24       Impact factor: 9.825
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.