OBJECTIVE: Gender and sex hormones influence the development of obesity and metabolic syndrome in humans and Göttingen minipigs. The aim of this study was to investigate possible gender differences in the metabolic response to a high energy diet in young Göttingen minipigs as a model of childhood/adolescent obesity. DESIGN AND METHODS: Nine-week-old male and female Göttingen minipigs were fed restrictedly on either a low energy diet (LED) or a high energy diet (HED) for 4 months (n = 5-7). Parameters of interest were fat percentage, visceral fat mass, plasma lipids and glucose tolerance, insulin resistance, and β-cell function measured by oral and intravenous glucose tolerance tests. RESULTS: At 11 to 12 weeks of age, after 2 weeks diet feeding, both genders on HED had increased fat percentage, glucose intolerance, decreased insulin sensitivity, and increased plasma levels of cholesterol and triglycerides (TGs). There was no gender difference in body weight (BW) or fat percentage, but males had lower glucose tolerance than females. After 3.5 to 4 months on the diets, the pigs on HED had increased BW, fat percentage, and visceral fat mass and were more glucose intolerant and insulin resistant than pigs on LED. Also increases in plasma cholesterol and TG levels were observed in the pigs on HED. Females had higher fat percentage and more visceral fat, were more insulin resistant, and had a more unfavorable lipid profile compared with males independent of diet. CONCLUSION: In conclusion, the young Göttingen minipig, and especially the female gender, seems to be a potential model for diet induced childhood/adolescent obesity and metabolic syndrome.
OBJECTIVE: Gender and sex hormones influence the development of obesity and metabolic syndrome in humans and Göttingen minipigs. The aim of this study was to investigate possible gender differences in the metabolic response to a high energy diet in young Göttingen minipigs as a model of childhood/adolescent obesity. DESIGN AND METHODS: Nine-week-old male and female Göttingen minipigs were fed restrictedly on either a low energy diet (LED) or a high energy diet (HED) for 4 months (n = 5-7). Parameters of interest were fat percentage, visceral fat mass, plasma lipids and glucose tolerance, insulin resistance, and β-cell function measured by oral and intravenous glucose tolerance tests. RESULTS: At 11 to 12 weeks of age, after 2 weeks diet feeding, both genders on HED had increased fat percentage, glucose intolerance, decreased insulin sensitivity, and increased plasma levels of cholesterol and triglycerides (TGs). There was no gender difference in body weight (BW) or fat percentage, but males had lower glucose tolerance than females. After 3.5 to 4 months on the diets, the pigs on HED had increased BW, fat percentage, and visceral fat mass and were more glucose intolerant and insulin resistant than pigs on LED. Also increases in plasma cholesterol and TG levels were observed in the pigs on HED. Females had higher fat percentage and more visceral fat, were more insulin resistant, and had a more unfavorable lipid profile compared with males independent of diet. CONCLUSION: In conclusion, the young Göttingen minipig, and especially the female gender, seems to be a potential model for diet induced childhood/adolescent obesity and metabolic syndrome.
Authors: Berit Ø Christoffersen; Søren J Jensen; Trine P Ludvigsen; Sara K Nilsson; Anette B Grossi; Peter M H Heegaard Journal: Comp Med Date: 2015-08 Impact factor: 0.982
Authors: Paulo G Coelho; Benjamin Pippenger; Nick Tovar; Sietse-Jan Koopmans; Natalie M Plana; Dana T Graves; Steve Engebretson; Heleen M M van Beusekom; Paula G F P Oliveira; Michel Dard Journal: J Oral Maxillofac Surg Date: 2018-03-01 Impact factor: 1.895
Authors: David J Polhemus; Jessica M Bradley; Kazi N Islam; Luke P Brewster; John W Calvert; Ya-Xiong Tao; Carlos C Chang; Iraklis I Pipinos; Traci T Goodchild; David J Lefer Journal: Am J Physiol Heart Circ Physiol Date: 2015-04-24 Impact factor: 4.733
Authors: Harrie C M Boonen; Sophia G Moesgaard; Malene M Birck; Berit O Christoffersen; Susanna Cirera; Peter M H Heegaard; Tina Rødgaard Højbøge; Lars J Jensen; Alan Mortensen; Lisbeth Høier Olsen; Majid Sheykhzade; Jiaowei Tang; Jens Lykkesfeldt Journal: Pflugers Arch Date: 2014-03-05 Impact factor: 3.657
Authors: Rajash K Handa; Ziyue Liu; Bret A Connors; Mouhamad Alloosh; David P Basile; Johnathan D Tune; Michael Sturek; Andrew P Evan; James E Lingeman Journal: J Urol Date: 2014-09-22 Impact factor: 7.450