UNLABELLED: Excess weight gain during both pre- and postnatal life increases risk for obesity in later life. Although a number of gestational and early life contributors to this effect have been identified, there is a dearth of research to examine whether gestational factors and weight gain velocity in infancy exert independent effects on subsequent body composition and fat distribution. OBJECTIVE: To test the hypothesis that birth weight, as a proxy of prenatal weight gain, and rate of weight gain before 6 months would be associated with total and truncal adiposity at 12 months of age. DESIGN AND METHODS: Healthy, term infants (N = 47) were enrolled in the study and rate of weight gain (g/day) was assessed at 0-3 months, 3-6 months, and 6-12 months. RESULTS: Total and regional body composition were measured by dual-energy X-ray absorptiometry (DXA) at 12 months. Stepwise linear regression modeling indicated that lean mass at 12 months, after adjusting for child length, was predicted by rate of weight gain during each discrete period of infancy (P < 0.05), and by maternal pre-pregnancy BMI (P < 0.05). Total fat mass at 12 months was predicted by rate of weight gain during each discrete period (P < 0.01), and by older maternal age at delivery (P < 0.05). Trunk fat mass at 12 months, after adjusting for leg fat mass, was predicted by rate of weight gain from 0-3 months and 3-6 months (P < 0.05). CONCLUSION: Results suggest that growth during early infancy may be a critical predictor of subsequent body composition and truncal fat distribution.
UNLABELLED: Excess weight gain during both pre- and postnatal life increases risk for obesity in later life. Although a number of gestational and early life contributors to this effect have been identified, there is a dearth of research to examine whether gestational factors and weight gain velocity in infancy exert independent effects on subsequent body composition and fat distribution. OBJECTIVE: To test the hypothesis that birth weight, as a proxy of prenatal weight gain, and rate of weight gain before 6 months would be associated with total and truncal adiposity at 12 months of age. DESIGN AND METHODS: Healthy, term infants (N = 47) were enrolled in the study and rate of weight gain (g/day) was assessed at 0-3 months, 3-6 months, and 6-12 months. RESULTS: Total and regional body composition were measured by dual-energy X-ray absorptiometry (DXA) at 12 months. Stepwise linear regression modeling indicated that lean mass at 12 months, after adjusting for child length, was predicted by rate of weight gain during each discrete period of infancy (P < 0.05), and by maternal pre-pregnancy BMI (P < 0.05). Total fat mass at 12 months was predicted by rate of weight gain during each discrete period (P < 0.01), and by older maternal age at delivery (P < 0.05). Trunk fat mass at 12 months, after adjusting for leg fat mass, was predicted by rate of weight gain from 0-3 months and 3-6 months (P < 0.05). CONCLUSION: Results suggest that growth during early infancy may be a critical predictor of subsequent body composition and truncal fat distribution.
Authors: Alexander G Fiks; Rachel S Gruver; Chanelle T Bishop-Gilyard; Justine Shults; Senbagam Virudachalam; Andrew W Suh; Marsha Gerdes; Gurpreet K Kalra; Patricia A DeRusso; Alexandra Lieberman; Daniel Weng; Michal A Elovitz; Robert I Berkowitz; Thomas J Power Journal: Child Obes Date: 2017-05-30 Impact factor: 2.992
Authors: L A Barbour; T L Hernandez; R M Reynolds; M S Reece; C Chartier-Logan; M K Anderson; T Kelly; J E Friedman; R E Van Pelt Journal: Pediatr Obes Date: 2015-07-22 Impact factor: 4.000
Authors: P F O'Tierney-Ginn; D Davina; M Gillingham; D J P Barker; C Morris; K L Thornburg Journal: J Dev Orig Health Dis Date: 2017-03-16 Impact factor: 2.401
Authors: Elvira Isganaitis; Sarah Venditti; Tucker J Matthews; Carles Lerin; Ellen W Demerath; David A Fields Journal: Am J Clin Nutr Date: 2019-07-01 Impact factor: 7.045
Authors: Mya-Thway Tint; Leigh C Ward; Shu E Soh; Izzuddin M Aris; Amutha Chinnadurai; Seang Mei Saw; Peter D Gluckman; Keith M Godfrey; Yap-Seng Chong; Michael S Kramer; Fabian Yap; Barbara Lingwood; Yung Seng Lee Journal: Br J Nutr Date: 2016-02-09 Impact factor: 3.718