Literature DB >> 23505079

Panton-Valentine leukocidin Staphylococcus causing fatal necrotising pneumonia in a young boy.

Shahzad Haider1, David Wright.   

Abstract

Panton-Valentine leukocidin (PVL) toxin producing strains of Staphylococcus aureus are known to cause skin and soft tissue infection. They can also cause necrotising pneumonia in otherwise healthy individuals. Here we report a case of severe, necrotising, haemorrhagic pneumonia in a 12-year-old boy who presented with a four-day history of a sore throat and fever. During his admission he deteriorated and needed full ventilatory support but despite all efforts he died. Postmortem examination lung swabs confirmed the presence of PVL-associated S aureus. There is a need to improve awareness of this disease among medical practitioners as early diagnosis and appropriate management can save lives.

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Year:  2013        PMID: 23505079      PMCID: PMC3618712          DOI: 10.1136/bcr-2012-007655

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  15 in total

1.  Knowledge of Panton-Valentine leukocidin-associated Staphylococcus aureus infections among paediatric registrars in England.

Authors:  H R Freeman; F A Hutchings; S C Marriage
Journal:  Arch Dis Child       Date:  2010-07-23       Impact factor: 3.791

2.  Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK.

Authors:  A Cunnington; T Brick; M Cooper; J Danin; D Hunt; A Jeanes; A M Kearns; M Nolan; H Lyall
Journal:  J Infect       Date:  2009-05-23       Impact factor: 6.072

3.  Follow up of cases of PVL-positive Staphylococcus aureus is not worthwhile.

Authors:  S Millership; A Cummins; D Irwin; A Kearns; P English
Journal:  J Infect       Date:  2011-01-31       Impact factor: 6.072

4.  Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.

Authors:  Yves Gillet; Bertrand Issartel; Philippe Vanhems; Jean-Christophe Fournet; Gerard Lina; Michèle Bes; François Vandenesch; Yves Piémont; Nicole Brousse; Daniel Floret; Jerome Etienne
Journal:  Lancet       Date:  2002-03-02       Impact factor: 79.321

5.  Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection.

Authors:  Blanca E Gonzalez; Kristina G Hulten; Megan K Dishop; Linda B Lamberth; Wendy A Hammerman; Edward O Mason; Sheldon L Kaplan
Journal:  Clin Infect Dis       Date:  2005-07-29       Impact factor: 9.079

6.  Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia.

Authors:  G Lina; Y Piémont; F Godail-Gamot; M Bes; M O Peter; V Gauduchon; F Vandenesch; J Etienne
Journal:  Clin Infect Dis       Date:  1999-11       Impact factor: 9.079

7.  Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease.

Authors:  A Holmes; M Ganner; S McGuane; T L Pitt; B D Cookson; A M Kearns
Journal:  J Clin Microbiol       Date:  2005-05       Impact factor: 5.948

8.  Severe community-acquired pneumonia caused by Panton-Valentine leukocidin-positive Staphylococcus aureus: first reported case in the United Kingdom.

Authors:  J L Klein; Z Petrovic; D Treacher; J Edgeworth
Journal:  Intensive Care Med       Date:  2003-05-29       Impact factor: 17.440

9.  Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine Leucocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus.

Authors:  Farah Mushtaq; Sandra Hildrew; Gabriel Okugbeni; Richard W Ellis; Sanjay Deshpande
Journal:  Acta Paediatr       Date:  2008-07       Impact factor: 2.299

10.  Factors predicting mortality in necrotizing community-acquired pneumonia caused by Staphylococcus aureus containing Panton-Valentine leukocidin.

Authors:  Yves Gillet; Philippe Vanhems; Gerard Lina; Michele Bes; Francois Vandenesch; Daniel Floret; Jerome Etienne
Journal:  Clin Infect Dis       Date:  2007-06-15       Impact factor: 9.079

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  7 in total

1.  Serious life-threatening multifocal infection in a child, caused by Panton-Valentine leucocidin-producing Staphylococcus aureus (PVL-MSSA).

Authors:  Neda Irenji; Suresh Kumar Gopala Pillai; Jennifer Susan West-Jones
Journal:  BMJ Case Rep       Date:  2018-06-05

2.  Successful management of Panton-Valentine leukocidine-positive necrotising pneumonia and A/H1N12009 influenzavirus coinfection in adult.

Authors:  Karena Riedweg-Moreno; Frederic Wallet; Caroline Blazejewski; Anne Goffard
Journal:  BMJ Case Rep       Date:  2014-01-16

3.  Community-associated Staphylococcus aureus pneumonia among Greek children: epidemiology, molecular characteristics, treatment, and outcome.

Authors:  A G Doudoulakakis; D Bouras; E Drougka; M Kazantzi; A Michos; A Charisiadou; I Spiliopoulou; E Lebessi; M Tsolia
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-05-02       Impact factor: 3.267

4.  Panton-Valentine leukocidin in community and hospital-acquired Staphylococcus aureus strains.

Authors:  Tuncer Özekinci; Tuba Dal; Keramettin Yanık; Nida Özcan; Şükran Can; Alicem Tekin; Halil İbrahim Yıldırım; İdris Kandemir
Journal:  Biotechnol Biotechnol Equip       Date:  2014-11-07       Impact factor: 1.632

Review 5.  Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.

Authors:  Hefa Mangzira Kemung; Loh Teng-Hern Tan; Tahir Mehmood Khan; Kok-Gan Chan; Priyia Pusparajah; Bey-Hing Goh; Learn-Han Lee
Journal:  Front Microbiol       Date:  2018-09-24       Impact factor: 5.640

6.  Subscapular Abscess Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus: An Atypical Presentation.

Authors:  Kamal Patel; Emma Spowart; Dana Sochorova; Nadia Diego; Georgios Mamarelis; Mohammad Zain Sohail
Journal:  Case Rep Orthop       Date:  2018-06-10

Review 7.  Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature.

Authors:  Massimo Luca Castellazzi; Samantha Bosis; Irene Borzani; Claudia Tagliabue; Raffaella Pinzani; Paola Marchisio; Giada Maria di Pietro
Journal:  Ital J Pediatr       Date:  2021-07-17       Impact factor: 2.638

  7 in total

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