BACKGROUND: Tobacco smoke chemicals may influence vitamin D metabolism and function, and conversely vitamin D may modify the carcinogenicity of tobacco smoke chemicals. We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population. METHODS: A prospective population-based cohort of 9791 individuals from the Copenhagen City Heart Study who were free of cancer at baseline was followed from 1981-1983 until December 2008 with 100% complete follow-up. RESULTS: During up to 28 years of follow-up, 1081 participants developed a tobacco-related cancer and 1506 developed other cancers. Decreasing 25(OH)D concentrations, subdivided by clinical categories or by seasonally adjusted percentile categories, were associated with increasing cumulative incidence of tobacco-related cancer (log-rank trend P = 2 × 10(-6) and P = 5 × 10(-9)). Multivariable adjusted hazard ratios of tobacco-related cancer were 1.75 (95% CI, 1.33-2.30) for 25(OH)D <5 vs ≥20 ng/mL, and 2.07 (1.63-2.62) for ≤5th vs >66th percentile. Also, multivariable adjusted hazard ratios for a 50% reduction in 25(OH)D were 1.20 (1.13-1.28) for any tobacco-related cancer, 1.19 (95% CI, 1.09-1.31) for lung cancer, 1.44 (1.19-1.73) for head and neck cancer, 1.28 (1.06-1.54) for bladder cancer, 1.34 (1.04-1.73) for kidney cancer, and 0.95 (0.89-1.01) for other cancers. CONCLUSIONS: Lower plasma 25(OH)D was associated with higher risk of tobacco-related cancers, but not with risk of other cancers.
BACKGROUND:Tobacco smoke chemicals may influence vitamin D metabolism and function, and conversely vitamin D may modify the carcinogenicity of tobacco smoke chemicals. We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population. METHODS: A prospective population-based cohort of 9791 individuals from the Copenhagen City Heart Study who were free of cancer at baseline was followed from 1981-1983 until December 2008 with 100% complete follow-up. RESULTS: During up to 28 years of follow-up, 1081 participants developed a tobacco-related cancer and 1506 developed other cancers. Decreasing 25(OH)D concentrations, subdivided by clinical categories or by seasonally adjusted percentile categories, were associated with increasing cumulative incidence of tobacco-related cancer (log-rank trend P = 2 × 10(-6) and P = 5 × 10(-9)). Multivariable adjusted hazard ratios of tobacco-related cancer were 1.75 (95% CI, 1.33-2.30) for 25(OH)D <5 vs ≥20 ng/mL, and 2.07 (1.63-2.62) for ≤5th vs >66th percentile. Also, multivariable adjusted hazard ratios for a 50% reduction in 25(OH)D were 1.20 (1.13-1.28) for any tobacco-related cancer, 1.19 (95% CI, 1.09-1.31) for lung cancer, 1.44 (1.19-1.73) for head and neck cancer, 1.28 (1.06-1.54) for bladder cancer, 1.34 (1.04-1.73) for kidney cancer, and 0.95 (0.89-1.01) for other cancers. CONCLUSIONS: Lower plasma 25(OH)D was associated with higher risk of tobacco-related cancers, but not with risk of other cancers.
Authors: Stephanie J Weinstein; Mark P Purdue; Stephanie A Smith-Warner; Alison M Mondul; Amanda Black; Jiyoung Ahn; Wen-Yi Huang; Ronald L Horst; William Kopp; Helen Rager; Regina G Ziegler; Demetrius Albanes Journal: Int J Cancer Date: 2014-09-02 Impact factor: 7.396
Authors: Stephanie J Weinstein; Alison M Mondul; Kai Yu; Tracy M Layne; Christian C Abnet; Neal D Freedman; Racheal Z Stolzenberg-Solomon; Unhee Lim; Mitchell H Gail; Demetrius Albanes Journal: Eur J Epidemiol Date: 2018-08-02 Impact factor: 8.082
Authors: José Manuel Ordóñez-Mena; Ben Schöttker; Veronika Fedirko; Mazda Jenab; Anja Olsen; Jytte Halkjær; Ellen Kampman; Lisette de Groot; Eugene Jansen; H Bas Bueno-de-Mesquita; Petra H Peeters; Galatios Siganos; Tom Wilsgaard; Laura Perna; Bernd Holleczek; Ulrika Pettersson-Kymmer; Philippos Orfanos; Antonia Trichopoulou; Paolo Boffetta; Hermann Brenner Journal: Eur J Epidemiol Date: 2015-05-15 Impact factor: 8.082
Authors: Ting-Yuan David Cheng; Xiaoling Song; Shirley A A Beresford; Gloria Y F Ho; Karen C Johnson; Mridul Datta; Rowan T Chlebowski; Jean Wactawski-Wende; Lihong Qi; Marian L Neuhouser Journal: Cancer Causes Control Date: 2017-09-12 Impact factor: 2.506
Authors: Irene Orlow; Anne S Reiner; Nancy E Thomas; Pampa Roy; Peter A Kanetsky; Li Luo; Susan Paine; Bruce K Armstrong; Anne Kricker; Loraine D Marrett; Stefano Rosso; Roberto Zanetti; Stephen B Gruber; Hoda Anton-Culver; Richard P Gallagher; Terence Dwyer; Klaus Busam; Colin B Begg; Marianne Berwick Journal: Carcinogenesis Date: 2015-10-31 Impact factor: 4.944