Literature DB >> 23503420

New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides.

Benoît Métayer1, Agnès Mingot, Daniella Vullo, Claudiu T Supuran, Sébastien Thibaudeau.   

Abstract

Tertiary substituted (fluorinated) benzenesulfonamides were synthesized in superacid HF/SbF5 and tested as inhibitors of human carbonic anhydrases (hCAs, EC 4.2.1.1). Strong selectivity toward tumor-associated hCA IX, without inhibiting the offtarget hCA II, was observed, pointing out to a new mechanism of action compared to classical sulfonamides.

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Year:  2013        PMID： 23503420     DOI： 10.1039/c3cc40858b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

Authors:  Melissa A Pinard; Mayank Aggarwal; Brian P Mahon; Chingkuang Tu; Robert McKenna
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-09-23       Impact factor: 1.056

2.  Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.

Authors:  Benoit Métayer; Andrea Angeli; Agnès Mingot; Kévin Jouvin; Gwilherm Evano; Claudiu T Supuran; Sébastien Thibaudeau
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

3.  Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors.

Authors:  Morteza Abdoli; Murat Bozdag; Andrea Angeli; Claudiu T Supuran
Journal:  Metabolites       Date:  2018-06-01

4.  Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

Authors:  Melissa D'Ascenzio; Paolo Guglielmi; Simone Carradori; Daniela Secci; Rosalba Florio; Adriano Mollica; Mariangela Ceruso; Atilla Akdemir; Anatoly P Sobolev; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-26       Impact factor: 5.051

Review 5.  Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX.

Authors:  Joseph Lau; Kuo-Shyan Lin; François Bénard
Journal:  Theranostics       Date:  2017-09-26       Impact factor: 11.556

Review 6.  Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery.

Authors:  Hélène Carreyre; Grégoire Carré; Maurice Ouedraogo; Clarisse Vandebrouck; Jocelyn Bescond; Claudiu T Supuran; Sébastien Thibaudeau
Journal:  Molecules       Date:  2017-05-31       Impact factor: 4.411
  6 in total

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