Literature DB >> 23503166

Amino acid substitutions in GyrA and ParC are associated with fluoroquinolone resistance in Mycoplasma bovis isolates from Japanese dairy calves.

Toyotaka Sato1, Torahiko Okubo, Masaru Usui, Hidetoshi Higuchi, Yutaka Tamura.   

Abstract

We investigated the contribution of quinolone resistance-determining region (QRDR) mutations to fluoroquinolone (enrofloxacin, orbifloxacin and danofloxacin) susceptibility in 58 Mycoplasma bovis isolates from dairy cattle in Japan. Fluoroquinolone non-resistant isolates (fluoroquinolone-MICs≤2 μg/ml) possessed no QRDR mutations (19 isolates) or Ser83Leu in GyrA (32 isolates). Fluoroquinolone-resistant isolates (fluoroquinolone-MICs≥4 μg/ml) possessed Ser83Leu in GyrA and Ser81Pro in ParC (3 isolates) or Ser83Phe in GyrA and Ser80Ile in ParC (4 isolates). Laboratory-derived fluoroquinolone-resistant mutants selected from 2 isolates (possessing Ser83Leu in GyrA) had an amino acid substitution in ParC at the same position (Ser80Ile or Ser81Tyr) as fluoroquinolone-resistant isolates, suggesting a concurrent amino acid substitution in ParC (Ser80 or Ser81) is important in fluoroquinolone resistance in M. bovis isolates.

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Year:  2013        PMID： 23503166     DOI： 10.1292/jvms.12-0508

Source DB:  PubMed          Journal:  J Vet Med Sci        ISSN： 0916-7250            Impact factor:   1.267


  13 in total

1.  Mutations Associated with Decreased Susceptibility to Seven Antimicrobial Families in Field and Laboratory-Derived Mycoplasma bovis Strains.

Authors:  Kinga M Sulyok; Zsuzsa Kreizinger; Enikő Wehmann; Inna Lysnyansky; Krisztián Bányai; Szilvia Marton; Ákos Jerzsele; Zsuzsanna Rónai; Ibolya Turcsányi; László Makrai; Szilárd Jánosi; Sára Ágnes Nagy; Miklós Gyuranecz
Journal:  Antimicrob Agents Chemother       Date:  2017-01-24       Impact factor: 5.191

2.  Characterization of Mutations in DNA Gyrase and Topoisomerase IV in Field Strains and In Vitro Selected Quinolone-Resistant Mycoplasma hyorhinis Mutants.

Authors:  Jun Li; Yanna Wei; Jia Wang; Yao Li; Guoqing Shao; Zhixin Feng; Qiyan Xiong
Journal:  Antibiotics (Basel)       Date:  2022-04-07

3.  Alterations in the Quinolone Resistance-Determining Regions and Fluoroquinolone Resistance in Clinical Isolates and Laboratory-Derived Mutants of Mycoplasma bovis: Not All Genotypes May Be Equal.

Authors:  Dima Khalil; Claire A M Becker; Florence Tardy
Journal:  Appl Environ Microbiol       Date:  2015-12-04       Impact factor: 4.792

4.  Pharmacokinetics in plasma and alveolar regions of a healthy calf intramuscularly administered a single dose of orbifloxacin.

Authors:  Tetsuro Kuramae; Shingo Ishikawa; Aki Kono; Seiji Hobo
Journal:  J Vet Med Sci       Date:  2022-01-28       Impact factor: 1.267

5.  Chromosomal transfers in mycoplasmas: when minimal genomes go mobile.

Authors:  Emilie Dordet-Frisoni; Eveline Sagné; Eric Baranowski; Marc Breton; Laurent Xavier Nouvel; Alain Blanchard; Marc Serge Marenda; Florence Tardy; Pascal Sirand-Pugnet; Christine Citti
Journal:  mBio       Date:  2014-11-25       Impact factor: 7.867

6.  Fluoroquinolone resistance mechanism of clinical isolates and selected mutants of Pasteurella multocida from bovine respiratory disease in China.

Authors:  Ling-Cong Kong; Duo Gao; Yun-Hang Gao; Shu-Ming Liu; Hong-Xia Ma
Journal:  J Vet Med Sci       Date:  2014-09-17       Impact factor: 1.267

7.  Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae.

Authors:  Ram Prosad Chakrabarty; Munawar Sultana; Saadlee Shehreen; Selina Akter; M Anwar Hossain
Journal:  AMB Express       Date:  2016-12-21       Impact factor: 3.298

8.  Genome-Wide Association Study Reveals Genetic Markers for Antimicrobial Resistance in Mycoplasma bovis.

Authors:  Jade Bokma; Nick Vereecke; Hans Nauwynck; Freddy Haesebrouck; Sebastiaan Theuns; Bart Pardon; Filip Boyen
Journal:  Microbiol Spectr       Date:  2021-10-06

Review 9.  Mycoplasma bovis: Mechanisms of Resistance and Trends in Antimicrobial Susceptibility.

Authors:  Inna Lysnyansky; Roger D Ayling
Journal:  Front Microbiol       Date:  2016-04-27       Impact factor: 5.640

10.  Antimicrobial susceptibility and molecular characterization of macrolide resistance of Mycoplasma bovis isolates from multiple provinces in China.

Authors:  Ling-Cong Kong; Duo Gao; Bo-Yan Jia; Zi Wang; Yun-Hang Gao; Zhi-Hua Pei; Shu-Ming Liu; Jiu-Qing Xin; Hong-Xia Ma
Journal:  J Vet Med Sci       Date:  2015-09-07       Impact factor: 1.267
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