Literature DB >> 23502559

Synthetic genomics and the construction of a synthetic bacterial cell.

John I Glass1.   

Abstract

The first synthetic cellular organism was created in 2010 and based on a very small, very simple bacterium called Mycoplasma mycoides. The bacterium was called synthetic because its DNA genome was chemically synthesized rather than replicated from an existing template DNA, as occurs in all other known cellular life on Earth. The experiment was undertaken in order to develop a system that would allow creation of a minimal bacterial cell that could lead to a better understand of the first principles of cellular life. The effort resulted in new synthetic genomics techniques called genome assembly and genome transplantation. The ability of scientists to design and build bacteria opens new possibilities for creating microbes to solve human problems.

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Year:  2012        PMID: 23502559     DOI: 10.1353/pbm.2012.0040

Source DB:  PubMed          Journal:  Perspect Biol Med        ISSN: 0031-5982            Impact factor:   1.416


  3 in total

Review 1.  Designer microbes for biosynthesis.

Authors:  Maureen B Quin; Claudia Schmidt-Dannert
Journal:  Curr Opin Biotechnol       Date:  2014-03-16       Impact factor: 9.740

2.  All-in-one construct for genome engineering using Cre-lox technology.

Authors:  Ana M Mariscal; Luis González-González; Enrique Querol; Jaume Piñol
Journal:  DNA Res       Date:  2016-04-15       Impact factor: 4.458

3.  Predicting the minimal translation apparatus: lessons from the reductive evolution of mollicutes.

Authors:  Henri Grosjean; Marc Breton; Pascal Sirand-Pugnet; Florence Tardy; François Thiaucourt; Christine Citti; Aurélien Barré; Satoko Yoshizawa; Dominique Fourmy; Valérie de Crécy-Lagard; Alain Blanchard
Journal:  PLoS Genet       Date:  2014-05-08       Impact factor: 5.917

  3 in total

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