Literature DB >> 23500073

Strongyloides stercoralis daf-2 encodes a divergent ortholog of Caenorhabditis elegans DAF-2.

Holman C Massey1, Najju Ranjit, Jonathan D Stoltzfus, James B Lok.   

Abstract

We hypothesise that developmental arrest in infectious larvae of parasitic nematodes is regulated by signalling pathways homologous to Caenorhabditis elegans DAF (dauer formation) pathways. Alignment of Strongyloides stercoralis (Ss) DAF-2 with DAF-2 of C. elegans and homologs of other species shows that most structural motifs in these insulin-like receptors are conserved. However, the catalytic domain of Ss-DAF-2 contains two substitutions (Q1242 and Q1256), that would result in constitutive dauer formation in C. elegans or diabetes in vertebrate animals. Ss-daf-2 also shows two alternately spliced isoforms, the constitutively expressed Ss-daf-2a, and Ss-daf-2b, which is only expressed in stages leading to parasitism.
Copyright © 2013 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23500073      PMCID： PMC3648630          DOI： 10.1016/j.ijpara.2013.01.008

Source DB:  PubMed          Journal:  Int J Parasitol        ISSN： 0020-7519            Impact factor:   3.981


  30 in total

1.  The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.

Authors:  K D Kimura; D L Riddle; G Ruvkun
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2011-11-28

2.  Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.

Authors:  Brian J Smith; Kun Huang; Geoffrey Kong; Shu Jin Chan; Satoe Nakagawa; John G Menting; Shi-Quan Hu; Jonathan Whittaker; Donald F Steiner; Panayotis G Katsoyannis; Colin W Ward; Michael A Weiss; Michael C Lawrence
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-26       Impact factor: 11.205

3.  A molecular evolutionary framework for the phylum Nematoda.

Authors:  M L Blaxter; P De Ley; J R Garey; L X Liu; P Scheldeman; A Vierstraete; J R Vanfleteren; L Y Mackey; M Dorris; L M Frisse; J T Vida; W K Thomas
Journal:  Nature       Date:  1998-03-05       Impact factor: 49.962

4.  The fork head transcription factor FKTF-1b from Strongyloides stercoralis restores DAF-16 developmental function to mutant Caenorhabditis elegans.

Authors:  Holman C Massey; Mahendra K Bhopale; Xinshe Li; Michelle Castelletto; James B Lok
Journal:  Int J Parasitol       Date:  2005-12-15       Impact factor: 3.981

5.  Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.

Authors:  C M Cahill; G Tzivion; N Nasrin; S Ogg; J Dore; G Ruvkun; M Alexander-Bridges
Journal:  J Biol Chem       Date:  2000-12-20       Impact factor: 5.157

Review 6.  Genetic analysis of insulin signaling in Drosophila.

Authors:  Robert S Garofalo
Journal:  Trends Endocrinol Metab       Date:  2002 May-Jun       Impact factor: 12.015

Review 7.  Insulin and aging.

Authors:  Andrzej Bartke
Journal:  Cell Cycle       Date:  2008-11-15       Impact factor: 4.534

8.  Morphogenesis of Strongyloides stercoralis infective larvae requires the DAF-16 ortholog FKTF-1.

Authors:  Michelle L Castelletto; Holman C Massey; James B Lok
Journal:  PLoS Pathog       Date:  2009-04-10       Impact factor: 6.823

9.  Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines.

Authors:  Hongguang Shao; Xinshe Li; Thomas J Nolan; Holman C Massey; Edward J Pearce; James B Lok
Journal:  PLoS Pathog       Date:  2012-08-09       Impact factor: 6.823

10.  A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.

Authors:  Miguel E Rentería; Neha S Gandhi; Pablo Vinuesa; Erik Helmerhorst; Ricardo L Mancera
Journal:  PLoS One       Date:  2008-11-07       Impact factor: 3.240
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  11 in total

1.  Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival.

Authors:  James B Lok
Journal:  Curr Clin Microbiol Rep       Date:  2016-10-07

2.  Strongyloides stercoralis and relatives: recent advances in general and molecular biology.

Authors:  James B Lok
Journal:  Curr Trop Med Rep       Date:  2014-09-25

Review 3.  The dauer hypothesis and the evolution of parasitism: 20 years on and still going strong.

Authors:  Matt Crook
Journal:  Int J Parasitol       Date:  2013-10-03       Impact factor: 3.981

4.  Hc-daf-2 encodes an insulin-like receptor kinase in the barber's pole worm, Haemonchus contortus, and restores partial dauer regulation.

Authors:  Facai Li; James B Lok; Robin B Gasser; Pasi K Korhonen; Mark R Sandeman; Deshi Shi; Rui Zhou; Xiangrui Li; Yanqin Zhou; Junlong Zhao; Min Hu
Journal:  Int J Parasitol       Date:  2014-04-12       Impact factor: 3.981

5.  Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus.

Authors:  Fa-Cai Li; Robin B Gasser; James B Lok; Pasi K Korhonen; Yi-Fan Wang; Fang-Yuan Yin; Li He; Rui Zhou; Jun-Long Zhao; Min Hu
Journal:  Parasit Vectors       Date:  2014-11-12       Impact factor: 3.876

6.  Identification and characterization of alternative splicing in parasitic nematode transcriptomes.

Authors:  Sahar Abubucker; Samantha N McNulty; Bruce A Rosa; Makedonka Mitreva
Journal:  Parasit Vectors       Date:  2014-04-01       Impact factor: 3.876

7.  cGMP and NHR signaling co-regulate expression of insulin-like peptides and developmental activation of infective larvae in Strongyloides stercoralis.

Authors:  Jonathan D Stoltzfus; Stephen M Bart; James B Lok
Journal:  PLoS Pathog       Date:  2014-07-10       Impact factor: 6.823

8.  Toward understanding the functional role of Ss-RIOK-1, a RIO protein kinase-encoding gene of Strongyloides stercoralis.

Authors:  Wang Yuan; James B Lok; Jonathan D Stoltzfus; Robin B Gasser; Fang Fang; Wei-Qiang Lei; Rui Fang; Yan-Qin Zhou; Jun-Long Zhao; Min Hu
Journal:  PLoS Negl Trop Dis       Date:  2014-08-07

9.  Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1).

Authors:  Fa-Cai Li; Robin B Gasser; James B Lok; Pasi K Korhonen; Li He; Wen-Da Di; Fang-Yuan Yin; Rui Zhou; Yan-Qin Zhou; Jun-Long Zhao; Min Hu
Journal:  Parasit Vectors       Date:  2016-02-03       Impact factor: 3.876

Review 10.  Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing.

Authors:  J B Lok; H Shao; H C Massey; X Li
Journal:  Parasitology       Date:  2016-03-22       Impact factor: 3.234
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