Literature DB >> 22123849

The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.

K D Kimura1, D L Riddle, G Ruvkun.   

Abstract

A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly in the nervous system, consistent with the assignment of DAF-2 pathway regulation of longevity to the nervous system. DAF-2 abundance in the nervous system is dependent on food intake, showing environmental modulation of pathway signaling. DAF-2 abundance is not dependent on downstream PI-3 kinase to DAF-16 transcription factor signaling. The modulation of DAF-2 protein level by nutritional status may constitute an important component in the irreversible commitment to dauer arrest.

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Year:  2011        PMID： 22123849     DOI： 10.1101/sqb.2011.76.010660

Source DB:  PubMed          Journal:  Cold Spring Harb Symp Quant Biol        ISSN： 0091-7451


  21 in total

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