PURPOSE OF REVIEW: This article provides an update on basal cell carcinoma (BCC), with a focus on the advanced BCC (aBCC), and the recent progress with targeted hedgehog signaling pathway inhibition for treatment of aBCC. RECENT FINDINGS: The hedgehog signaling pathway is aberrantly activated in most BCC tumors providing an attractive therapeutic target in this cancer. Recently developed targeted hedgehog pathway inhibitors have demonstrated remarkable efficacy in the treatment of aBCC and the first oral hedgehog pathway inhibitor vismodegib was granted the US Food and Drug Administration (FDA) approval. Toxicities of the current hedgehog pathway inhibitors are mostly mild to moderate, but with prolonged treatment can pose a therapeutic challenge. SUMMARY: Hedgehog pathway inhibition is a novel and powerful approach for treatment of aBCC. Current research efforts aim to enhance the activity and minimize toxicity of this promising new therapy.
PURPOSE OF REVIEW: This article provides an update on basal cell carcinoma (BCC), with a focus on the advanced BCC (aBCC), and the recent progress with targeted hedgehog signaling pathway inhibition for treatment of aBCC. RECENT FINDINGS: The hedgehog signaling pathway is aberrantly activated in most BCC tumors providing an attractive therapeutic target in this cancer. Recently developed targeted hedgehog pathway inhibitors have demonstrated remarkable efficacy in the treatment of aBCC and the first oral hedgehog pathway inhibitor vismodegib was granted the US Food and Drug Administration (FDA) approval. Toxicities of the current hedgehog pathway inhibitors are mostly mild to moderate, but with prolonged treatment can pose a therapeutic challenge. SUMMARY: Hedgehog pathway inhibition is a novel and powerful approach for treatment of aBCC. Current research efforts aim to enhance the activity and minimize toxicity of this promising new therapy.
Authors: Michael F Ochs; Jason E Farrar; Michael Considine; Yingying Wei; Soheil Meshinchi; Robert J Arceci Journal: IEEE/ACM Trans Comput Biol Bioinform Date: 2014 May-Jun Impact factor: 3.710
Authors: Anne Lynn S Chang; Sarah T Arron; Michael R Migden; James A Solomon; Simon Yoo; Bann-Mo Day; Edward F McKenna; Aleksandar Sekulic Journal: Orphanet J Rare Dis Date: 2016-09-01 Impact factor: 4.123
Authors: Mario E Lacouture; Brigitte Dréno; Paolo Antonio Ascierto; Reinhard Dummer; Nicole Basset-Seguin; Kate Fife; Scott Ernst; Lisa Licitra; Rogerio I Neves; Ketty Peris; Susana Puig; Jonas Sokolof; Aleksandar Sekulic; Axel Hauschild; Rainer Kunstfeld Journal: Oncologist Date: 2016-08-10