Literature DB >> 2349087

Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents.

R P Iyer1, B Uznanski, J Boal, C Storm, W Egan, M Matsukura, S Broder, G Zon, A Wilk, M Koziolkiewicz.   

Abstract

The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and (+/-)-butane 1, 3-diol, respectively), are described.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2349087      PMCID： PMC330810          DOI： 10.1093/nar/18.10.2855

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  11 in total

Review 1.  Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

Authors:  A R van der Krol; J N Mol; A R Stuitje
Journal:  Biotechniques       Date:  1988 Nov-Dec       Impact factor: 1.993

2.  Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

Authors:  M Takeshita; C N Chang; F Johnson; S Will; A P Grollman
Journal:  J Biol Chem       Date:  1987-07-25       Impact factor: 5.157

3.  Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide.

Authors:  C Majumdar; C A Stein; J S Cohen; S Broder; S H Wilson
Journal:  Biochemistry       Date:  1989-02-07       Impact factor: 3.162

Review 4.  Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression--a review.

Authors:  J J Toulmé; C Hélène
Journal:  Gene       Date:  1988-12-10       Impact factor: 3.688

5.  Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

Authors:  M Matsukura; G Zon; K Shinozuka; M Robert-Guroff; T Shimada; C A Stein; H Mitsuya; F Wong-Staal; J S Cohen; S Broder
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

6.  Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

Authors:  P C Zamecnik; J Goodchild; Y Taguchi; P S Sarin
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

7.  Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus.

Authors:  S Agrawal; J Goodchild; M P Civeira; A H Thornton; P S Sarin; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

8.  Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis.

Authors:  T A Millican; G A Mock; M A Chauncey; T P Patel; M A Eaton; J Gunning; S D Cutbush; S Neidle; J Mann
Journal:  Nucleic Acids Res       Date:  1984-10-11       Impact factor: 16.971

9.  Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

Authors:  M Matsukura; K Shinozuka; G Zon; H Mitsuya; M Reitz; J S Cohen; S Broder
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

10.  Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

Authors:  S Agrawal; T Ikeuchi; D Sun; P S Sarin; A Konopka; J Maizel; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205
View more
  4 in total

1.  Delivery of siRNA to the mouse lung via a functionalized lipopolyamine.

Authors:  Kevin J Polach; Majed Matar; Jennifer Rice; Gregory Slobodkin; Jeff Sparks; Richard Congo; Angela Rea-Ramsey; Diane McClure; Elaine Brunhoeber; Monika Krampert; Andrea Schuster; Kerstin Jahn-Hofmann; Matthias John; Hans-Peter Vornlocher; Jason G Fewell; Khursheed Anwer; Anke Geick
Journal:  Mol Ther       Date:  2011-10-11       Impact factor: 11.454

2.  Gene-targeted inhibition of transactivation of human immunodeficiency virus type-1 (HIV-1)-LTR by antisense oligonucleotides.

Authors:  I Demirhan; O Hasselmayer; D Hofmann; A Chandra; F P Svinarchuk; V V Vlassov; J Engels; P Chandra
Journal:  Virus Genes       Date:  1995-01       Impact factor: 2.332

3.  Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element.

Authors:  T Vickers; B F Baker; P D Cook; M Zounes; R W Buckheit; J Germany; D J Ecker
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

4.  Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent.

Authors:  L Benimetskaya; J L Tonkinson; M Koziolkiewicz; B Karwowski; P Guga; R Zeltser; W Stec; C A Stein
Journal:  Nucleic Acids Res       Date:  1995-11-11       Impact factor: 16.971
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.