Literature DB >> 23489632

Photoinitiated release of an aziridinium ion precursor for the temporally controlled alkylation of nucleophiles.

Stephen T McCarron1, Mariel Feliciano, Jeffreys N Johnson, James J Chambers.   

Abstract

A photo-activatable aziridinium precursor has been developed to investigate the possibility of a photo-initiated traditional nucleophilic reaction. The photolysis of a quaternary amine yields a tertiary amine and has allowed us to temporally control aziridinium formation and subsequent alkylation of a colorimetric nucleophilic reporter molecule. We have also used this photo-initiated reaction to alkylate a sulfhydryl group. This new photo-initiated alkylation strategy is water-soluble and expands the toolkit of photo-activated crosslinkers for protein labeling research. Published by Elsevier Ltd.

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Year:  2013        PMID： 23489632      PMCID： PMC3609034          DOI： 10.1016/j.bmcl.2013.02.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  29 in total

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Review 8.  Benzophenone photophores in biochemistry.

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  1 in total

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