| Literature DB >> 23489626 |
Dongyup Hahn1, Dong Hwan Won, Bora Mun, Hiyoung Kim, Chulkyeong Han, Weihong Wang, Taeho Chun, Sunhee Park, Dajeong Yoon, Hyukjae Choi, Sang-Jip Nam, Merrick Ekins, Jungwook Chin, Heonjoong Kang.
Abstract
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.Entities:
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Year: 2013 PMID： 23489626 DOI： 10.1016/j.bmcl.2013.02.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823