BACKGROUND: Adaptive immunity plays a critical role in atherosclerosis and T helper 17 (Th17) cells, a new T-cell lineage, are recently reported to be involved in atherosclerosis. However, the mechanism underlying Th17 inflammation in atherosclerosis remains largely unknown. Thymic stromal lymphopoietin (TSLP) is a novel IL-7-like cytokine and mainly responsible for Th2 inflammation in many inflammatory diseases. METHODS AND RESULTS: Immunohistochemistry showed that TSLP over-expressed in human atherosclerotic lesion and could be induced by ox-LDL in human vascular smooth muscle cells (HVSMCs) and human umbilical vein endothelial cells (HUVECs). TSLP, in turn, could activate dendritic cells (DCs) to differentiate Th17 inflammation in naive CD4(+) T cells. CONCLUSION: TSLP induced by ox-LDL could promote Th17 immune response in vitro, which may be implicated in Th17 inflammation in atherosclerosis.
BACKGROUND: Adaptive immunity plays a critical role in atherosclerosis and T helper 17 (Th17) cells, a new T-cell lineage, are recently reported to be involved in atherosclerosis. However, the mechanism underlying Th17 inflammation in atherosclerosis remains largely unknown. Thymic stromal lymphopoietin (TSLP) is a novel IL-7-like cytokine and mainly responsible for Th2 inflammation in many inflammatory diseases. METHODS AND RESULTS: Immunohistochemistry showed that TSLP over-expressed in humanatherosclerotic lesion and could be induced by ox-LDL in human vascular smooth muscle cells (HVSMCs) and human umbilical vein endothelial cells (HUVECs). TSLP, in turn, could activate dendritic cells (DCs) to differentiate Th17 inflammation in naive CD4(+) T cells. CONCLUSION:TSLP induced by ox-LDL could promote Th17 immune response in vitro, which may be implicated in Th17 inflammation in atherosclerosis.
Authors: Martin Steinmetz; Ludivine Laurans; Sarah Nordsiek; Lena Weiß; Bieke van der Veken; Padmapriya Ponnuswamy; Bruno Esposito; Marie Vandestienne; Andreas Giraud; Cristina Göbbel; Eva Steffen; Tobias Radecke; Stephane Potteaux; Georg Nickenig; Tienush Rassaf; Alain Tedgui; Ziad Mallat Journal: J Cell Mol Med Date: 2020-04-13 Impact factor: 5.310