| Literature DB >> 23484211 |
V Kh Khavinson1, S I Tarnovskaya, N S Linkova, V E Pronyaeva, L K Shataeva, P P Yakutseni.
Abstract
Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide-DNA interactions and to evaluate their quantitative characteristics. Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.Entities:
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Year: 2013 PMID： 23484211 DOI： 10.1007/s10517-013-1961-3
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804