OBJECTIVE: The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival. METHODS: The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records. RESULTS: The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P<0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression. CONCLUSION: MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients.
OBJECTIVE: The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival. METHODS: The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records. RESULTS: The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P<0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression. CONCLUSION:MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients.
Authors: Isabelle Iwanicki-Caron; Frédéric Di Fiore; Isabelle Roque; Emilie Astruc; Monica Stetiu; Aude Duclos; David Tougeron; Sandrine Saillard; Sébastien Thureau; Jacques Benichou; Bernard Paillot; Jean Pierre Basuyau; Pierre Michel Journal: J Clin Oncol Date: 2008-08-01 Impact factor: 44.544
Authors: Uta Drebber; Stephan E Baldus; Britt Nolden; Guido Grass; Elfriede Bollschweiler; Hans P Dienes; Arnulf H Hölscher; Stefan P Mönig Journal: Oncol Rep Date: 2008-06 Impact factor: 3.906