Jordi Merino1, Raimon Ferré, Josefa Girona, Dolors Aguas, Anna Cabré, Núria Plana, Angels Vinuesa, Daiana Ibarretxe, Josep Basora, Carme Buixadera, Lluís Masana. 1. From the 1 Vascular Medicine and Metabolism Unit and Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Institut d'Investigació Sanitària Pere Virgili, Rovira i Virgili University, Reus, Spain; 2Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain; 3Reus Esport i Lleure, Ajuntament de Reus, Spain; 4Atención Primaria, Institut Català de la Salut, Tarragona, Spain; and 5Institut d'Investigació en Atenció Primària Jordi Gol, Catalunya, Spain.
Abstract
OBJECTIVE: Some individuals with cardiovascular risk are unable to achieve even the lower internationally recommended level of physical activity (PA). We aimed to study the impact of a lower-than-advised level of PA on small artery vascular function and oxidative stress in overweight and obese postmenopausal women. METHODS: Forty-seven overweight and obese postmenopausal women completed a 4-month program of 1-hour low-intensity PA for 2 days per week. Before and after the intervention, PA level (metabolic equivalent tasks/h/wk), endogenous antioxidant status (superoxide dismutase and erythrocyte lysate and glutathione peroxidase erythrocyte lysate concentrations, superoxide dismutase plasma and glutathione peroxidase plasma [GPXa] activities, and oxidized low-density lipoprotein), asymmetrical dimethylarginine concentrations, endothelial function by small artery reactive hyperemia index (saRHI), and resting heart rate (RHR) were assessed. RESULTS: After the intervention, a significant increase in GPXa and decreases in asymmetrical dimethylarginine concentrations and RHR (P < 0.001 for all) were observed. Increases in PA were positively associated with increases in saRHI (r = 0.330, P = 0.027) and GPXa (r = 0.299, P = 0.05) and a decrease in RHR (r = -0.297, P = 0.047). Multivariate analyses showed that the independent predictors of saRHI improvement were an increase in PA (β = 2.63; 95% CI, 1.24-4.19; P = 0.019), a decrease in RHR (β = 1.96; 95% CI, 1.01-5.03; P = 0.048), and an increase in GPXa (β = 2.64; 95% CI, 1.18-5.08; P = 0.021). CONCLUSIONS: Even low-intensity PA improves antioxidant capacity, RHR, and saRHI in postmenopausal women. Advising postmenopausal women to increase their PA at any level seems warranted based on our preliminary and hypothesis-generating data.
OBJECTIVE: Some individuals with cardiovascular risk are unable to achieve even the lower internationally recommended level of physical activity (PA). We aimed to study the impact of a lower-than-advised level of PA on small artery vascular function and oxidative stress in overweight and obese postmenopausal women. METHODS: Forty-seven overweight and obese postmenopausal women completed a 4-month program of 1-hour low-intensity PA for 2 days per week. Before and after the intervention, PA level (metabolic equivalent tasks/h/wk), endogenous antioxidant status (superoxide dismutase and erythrocyte lysate and glutathione peroxidase erythrocyte lysate concentrations, superoxide dismutase plasma and glutathione peroxidase plasma [GPXa] activities, and oxidized low-density lipoprotein), asymmetrical dimethylarginine concentrations, endothelial function by small artery reactive hyperemia index (saRHI), and resting heart rate (RHR) were assessed. RESULTS: After the intervention, a significant increase in GPXa and decreases in asymmetrical dimethylarginine concentrations and RHR (P < 0.001 for all) were observed. Increases in PA were positively associated with increases in saRHI (r = 0.330, P = 0.027) and GPXa (r = 0.299, P = 0.05) and a decrease in RHR (r = -0.297, P = 0.047). Multivariate analyses showed that the independent predictors of saRHI improvement were an increase in PA (β = 2.63; 95% CI, 1.24-4.19; P = 0.019), a decrease in RHR (β = 1.96; 95% CI, 1.01-5.03; P = 0.048), and an increase in GPXa (β = 2.64; 95% CI, 1.18-5.08; P = 0.021). CONCLUSIONS: Even low-intensity PA improves antioxidant capacity, RHR, and saRHI in postmenopausal women. Advising postmenopausal women to increase their PA at any level seems warranted based on our preliminary and hypothesis-generating data.
Authors: Christine M Friedenreich; Vincent Pialoux; Qinggang Wang; Eileen Shaw; Darren R Brenner; Xavier Waltz; Shannon M Conroy; Rhys Johnson; Christy G Woolcott; Marc J Poulin; Kerry S Courneya Journal: BMJ Open Sport Exerc Med Date: 2016-10-24
Authors: Michael J LaMonte; Cora E Lewis; David M Buchner; Kelly R Evenson; Eileen Rillamas-Sun; Chongzhi Di; I-Min Lee; John Bellettiere; Marcia L Stefanick; Charles B Eaton; Barbara V Howard; Chloe Bird; Andrea Z LaCroix Journal: J Am Heart Assoc Date: 2017-10-17 Impact factor: 5.501
Authors: Steve Nguyen; John Bellettiere; Guangxing Wang; Chongzhi Di; Loki Natarajan; Michael J LaMonte; Andrea Z LaCroix Journal: J Am Heart Assoc Date: 2022-02-22 Impact factor: 6.106