A Dregan1, M C Gulliford. 1. King's College London, NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, Department of Primary Care and Public Health Sciences, London, UK.
Abstract
BACKGROUND: The objective of the present study was to estimate the association between different leisure-time physical activity (LTPA) parameters from 11 to 50 years and cognitive functioning in late mid-adulthood. METHOD: The study used a prospective birth cohort study including participants in the UK National Child Development Study (NCDS) from age 11 to 50 years. Standardized z scores for cognitive, memory and executive functioning at age 50 represented the primary outcome measures. Exposures included self-reported LTPA at ages 11, 16, 33, 42, 46 and 50 years. Analyses were adjusted for important confounders including educational attainment and long-standing illness. RESULTS: The adjusted difference in cognition score between women who reported LTPA for at least 4 days/week in five surveys or more and those who never reported LTPA for at least 4 days/week was 0.28 [95% confidence interval (CI) 0.20-0.35], 0.10 (95% CI 0.01-0.19) for memory score and 0.30 (95% CI 0.23-0.38) for executive functioning score. For men, the equivalent differences were: cognition 0.12 (95% CI 0.05-0.18), memory 0.06 (95% CI -0.02 to 0.14) and executive functioning 0.16 (95% CI 0.10-0.23). CONCLUSIONS: This study provides novel evidence about the lifelong association between LTPA and memory and executive functioning in mid-adult years. Participation in low-frequency and low-intensity LTPA was positively associated with cognitive functioning in late mid-adult years for men and women. The greatest benefit emerged from participating in lifelong intensive LTPA.
BACKGROUND: The objective of the present study was to estimate the association between different leisure-time physical activity (LTPA) parameters from 11 to 50 years and cognitive functioning in late mid-adulthood. METHOD: The study used a prospective birth cohort study including participants in the UK National Child Development Study (NCDS) from age 11 to 50 years. Standardized z scores for cognitive, memory and executive functioning at age 50 represented the primary outcome measures. Exposures included self-reported LTPA at ages 11, 16, 33, 42, 46 and 50 years. Analyses were adjusted for important confounders including educational attainment and long-standing illness. RESULTS: The adjusted difference in cognition score between women who reported LTPA for at least 4 days/week in five surveys or more and those who never reported LTPA for at least 4 days/week was 0.28 [95% confidence interval (CI) 0.20-0.35], 0.10 (95% CI 0.01-0.19) for memory score and 0.30 (95% CI 0.23-0.38) for executive functioning score. For men, the equivalent differences were: cognition 0.12 (95% CI 0.05-0.18), memory 0.06 (95% CI -0.02 to 0.14) and executive functioning 0.16 (95% CI 0.10-0.23). CONCLUSIONS: This study provides novel evidence about the lifelong association between LTPA and memory and executive functioning in mid-adult years. Participation in low-frequency and low-intensity LTPA was positively associated with cognitive functioning in late mid-adult years for men and women. The greatest benefit emerged from participating in lifelong intensive LTPA.
Authors: Garrett I Ash; Kevin L Joiner; Mary Savoye; Julien S Baker; James Gerosa; Emma Kleck; Neha S Patel; Lois S Sadler; Matthew Stults-Kolehmainen; Stuart A Weinzimer; Margaret Grey Journal: Pediatr Diabetes Date: 2019-04-09 Impact factor: 4.866
Authors: Emilie T Reas; Gail A Laughlin; Jaclyn Bergstrom; Donna Kritz-Silverstein; Erin L Richard; Elizabeth Barrett-Connor; Linda K McEvoy Journal: Age Ageing Date: 2019-03-01 Impact factor: 10.668
Authors: Mario Ortega; Laurie M Baker; Florin Vaida; Robert Paul; Brian Basco; Beau M Ances Journal: J Int Neuropsychol Soc Date: 2015-11 Impact factor: 2.892
Authors: Tina D Hoang; Jared Reis; Na Zhu; David R Jacobs; Lenore J Launer; Rachel A Whitmer; Stephen Sidney; Kristine Yaffe Journal: JAMA Psychiatry Date: 2016-01 Impact factor: 25.911
Authors: Sandra B Chapman; Sina Aslan; Jeffrey S Spence; Laura F Defina; Molly W Keebler; Nyaz Didehbani; Hanzhang Lu Journal: Front Aging Neurosci Date: 2013-11-12 Impact factor: 5.750