Antoniana Ursine Krettli1. 1. Professor Instituto Rene Rachou - Fundação Instituto Oswaldo Cruz -FIOCRUZ, Malaria Laboratory, Avenue Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190 002, Brazil +55 31 3349 7770 ; +55 31 3295 3115 ; akrettli@cpqrr.fiocruz.br.
Abstract
BACKGROUND: Malaria is the most important parasitic disease and its control depends on specific chemotherapy, now complicated by Plasmodium falciparum that has become resistant to most commonly available antimalarials. Treatment of the disease requires quinine or drug combinations of artemisinin derivatives and other antimalarials. Further drug resistance is expected. New active compounds need to be discovered. OBJECTIVE/ METHOD: To find new antimalarials from medicinal and randomly collected plants, crude extracts are screened against P. falciparum in cultures and in malaria animal models, following bioassays of purified fractions, and cytotoxicity tests. CONCLUSION: For antimalarial research, screening medicinal plants is more efficient than screening randomly chosen plants. Biomonitored fractionation allows selection of new active molecules identified as potential antimalarials in multidisciplinary projects in Brazil; no new molecule is available for human testing. The advantages of projects based on ethnopharmacology are discussed.
BACKGROUND:Malaria is the most important parasitic disease and its control depends on specific chemotherapy, now complicated by Plasmodium falciparum that has become resistant to most commonly available antimalarials. Treatment of the disease requires quinine or drug combinations of artemisinin derivatives and other antimalarials. Further drug resistance is expected. New active compounds need to be discovered. OBJECTIVE/ METHOD: To find new antimalarials from medicinal and randomly collected plants, crude extracts are screened against P. falciparum in cultures and in malaria animal models, following bioassays of purified fractions, and cytotoxicity tests. CONCLUSION: For antimalarial research, screening medicinal plants is more efficient than screening randomly chosen plants. Biomonitored fractionation allows selection of new active molecules identified as potential antimalarials in multidisciplinary projects in Brazil; no new molecule is available for human testing. The advantages of projects based on ethnopharmacology are discussed.
Authors: Julia Penna Coutinho; Anna Caroline Campos Aguiar; Pierre Alexandre dos Santos; Joaquim Corsino Lima; Maria Gabrielle Lima Rocha; Carlos Leomar Zani; Tânia Maria Almeida Alves; Antônio Euzébio Goulart Santana; Maria de Meneses Pereira; Antoniana Ursine Krettli Journal: Mem Inst Oswaldo Cruz Date: 2013-12 Impact factor: 2.743
Authors: Isabela P Ceravolo; Carlos L Zani; Flávio J B Figueiredo; Markus Kohlhoff; Antônio E G Santana; Antoniana U Krettli Journal: Malar J Date: 2018-11-26 Impact factor: 2.979
Authors: Talita P C Chierrito; Anna C C Aguiar; Isabel M de Andrade; Isabela P Ceravolo; Regina A C Gonçalves; Arildo J B de Oliveira; Antoniana U Krettli Journal: Malar J Date: 2014-04-14 Impact factor: 2.979