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Literature DB >> 23478957

Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma.

Jessica A O'Hara¹, Patrick McGann, Erik C Snesrud, Robert J Clifford, Paige E Waterman, Emil P Lesho, Yohei Doi.

Abstract

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23478957 PMCID： PMC3632941 DOI： 10.1128/AAC.00266-13

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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