BACKGROUND: Small-bowel cancer is uncommon and, accordingly, little is known about the epidemiology of this malignancy, especially by race and subtype. OBJECTIVE: The objective of this analysis was to describe the distribution of small-bowel cancer in the United States by demographic, pathological, and clinical features. DESIGN: This study was retrospective in design. SETTING: Data from 26 population-based cancer registries in the United States from 1995 to 2008 were used. PATIENTS: Patients diagnosed with small-bowel cancer (topography codes C17.0-17.3 and C17.8-17.9) were included. MAIN OUTCOME MEASURES: The primary outcomes measured were race- and histology-specific incidence (age-adjusted rate trends and age-specific rates) of small-bowel cancer. RESULTS: A total of 56,223 men and women diagnosed with small-bowel cancer were identified. The overall age-adjusted incidence rates for small-bowel cancer were 26.1 in men and 17.7 in women. Neuroendocrine tumors were the most common histological types of small-bowel cancer in men and women, followed by carcinoma, lymphoma, and sarcoma. In comparison with whites, the rate of small-bowel cancer was 42% greater in black men, 46% greater in black women, 34% lower in Asian-Pacific Islander men, and 37% lower in Asian-Pacific Islander women. Rates of small-bowel cancer were 24% lower in Hispanic men and 15% lower in Hispanic women than rates in non-Hispanics. The excess of small-bowel cancer in blacks and the deficit in Asian-Pacific Islanders were attributable mainly to the incidence of adenocarcinoma and carcinoid tumors. The incidence of GI stromal tumor was significantly higher among Asian-Pacific Islanders. CONCLUSIONS: This is one of the largest studies of small-bowel cancer to date. These cancer registry data showed substantial racial and ethnic variation in the incidence of histological subtypes of small-bowel malignancy that suggest possible etiologic diversity and/or disparities in detection.
BACKGROUND:Small-bowel cancer is uncommon and, accordingly, little is known about the epidemiology of this malignancy, especially by race and subtype. OBJECTIVE: The objective of this analysis was to describe the distribution of small-bowel cancer in the United States by demographic, pathological, and clinical features. DESIGN: This study was retrospective in design. SETTING: Data from 26 population-based cancer registries in the United States from 1995 to 2008 were used. PATIENTS: Patients diagnosed with small-bowel cancer (topography codes C17.0-17.3 and C17.8-17.9) were included. MAIN OUTCOME MEASURES: The primary outcomes measured were race- and histology-specific incidence (age-adjusted rate trends and age-specific rates) of small-bowel cancer. RESULTS: A total of 56,223 men and women diagnosed with small-bowel cancer were identified. The overall age-adjusted incidence rates for small-bowel cancer were 26.1 in men and 17.7 in women. Neuroendocrine tumors were the most common histological types of small-bowel cancer in men and women, followed by carcinoma, lymphoma, and sarcoma. In comparison with whites, the rate of small-bowel cancer was 42% greater in black men, 46% greater in black women, 34% lower in Asian-Pacific Islander men, and 37% lower in Asian-Pacific Islander women. Rates of small-bowel cancer were 24% lower in Hispanic men and 15% lower in Hispanic women than rates in non-Hispanics. The excess of small-bowel cancer in blacks and the deficit in Asian-Pacific Islanders were attributable mainly to the incidence of adenocarcinoma and carcinoid tumors. The incidence of GI stromal tumor was significantly higher among Asian-Pacific Islanders. CONCLUSIONS: This is one of the largest studies of small-bowel cancer to date. These cancer registry data showed substantial racial and ethnic variation in the incidence of histological subtypes of small-bowel malignancy that suggest possible etiologic diversity and/or disparities in detection.
Authors: L A Anderson; A Tavilla; H Brenner; S Luttmann; C Navarro; A T Gavin; B Holleczek; B T Johnston; M B Cook; F Bannon; M Sant Journal: Eur J Cancer Date: 2015-09-26 Impact factor: 9.162
Authors: Maryam Zenali; Michael J Overman; Asif Rashid; Russell B Broaddus; Hua Wang; Matthew H Katz; Jason B Fleming; James L Abbruzzese; Huamin Wang Journal: Hum Pathol Date: 2013-10-15 Impact factor: 3.466
Authors: Yunxia Lu; Amanda J Cross; Neil Murphy; Heinz Freisling; Ruth C Travis; Pietro Ferrari; Verena A Katzke; Rudolf Kaaks; Åsa Olsson; Ingegerd Johansson; Frida Renström; Salvatore Panico; Valeria Pala; Domenico Palli; Rosario Tumino; Petra H Peeters; Peter D Siersema; H B Bueno-de-Mesquita; Antonia Trichopoulou; Eleni Klinaki; Christos Tsironis; Antonio Agudo; Carmen Navarro; María-José Sánchez; Aurelio Barricarte; Marie-Christine Boutron-Ruault; Guy Fagherazzi; Antoine Racine; Elisabete Weiderpass; Marc J Gunter; Elio Riboli Journal: Cancer Causes Control Date: 2016-06-13 Impact factor: 2.506