Anne-Marie Bouvier1,2,3,4,5, Michel Robaszkiewicz6,7,8, Valérie Jooste9,10,11,6,12, Mélanie Cariou6,7, Antoine Drouillard9,10,11,12, Véronique Bouvier6,13, Jean-Baptiste Nousbaum6,7,8. 1. Digestive Cancer Registry of Burgundy, Dijon, France. anne-marie.bouvier@u-bourgogne.fr. 2. LNC UMR1231 EPICAD, Dijon, France. anne-marie.bouvier@u-bourgogne.fr. 3. University of Bourgogne Franche-Comté, UFR des sciences de santé, Dijon, France. anne-marie.bouvier@u-bourgogne.fr. 4. FRANCIM (French Network of cancer registries), Toulouse, France. anne-marie.bouvier@u-bourgogne.fr. 5. Dijon University Hospital, Dijon, France. anne-marie.bouvier@u-bourgogne.fr. 6. FRANCIM (French Network of cancer registries), Toulouse, France. 7. Digestive Cancer Registry of Finistère, EA 7479 SPURBO, University Hospital, Brest, France. 8. Department of Hepato-Gastroenterology, University Hospital La Cavale Blanche, Brest, France. 9. Digestive Cancer Registry of Burgundy, Dijon, France. 10. LNC UMR1231 EPICAD, Dijon, France. 11. University of Bourgogne Franche-Comté, UFR des sciences de santé, Dijon, France. 12. Dijon University Hospital, Dijon, France. 13. Digestive Tumour Registry of Calvados, Pôle recherche CHU Caen Normandie, INSERM-UCN 1086, Centre François Baclesse, Caen, France.
Abstract
BACKGROUND: Small bowel cancer is not a single entity. Population-based studies taking into account histological diversity are scarce. The aim of this study was to report on their trends in incidence by histology in France over the past 20 years. METHODS: All patients with a small bowel cancer diagnosed in 15 French administrative areas covered by a registry from the network of French cancer registries (FRANCIM) were included. Age-standardized incidence rates were estimated using the world standard population. Incidence rates were calculated by gender, age group, histology, and 5-year period. RESULTS: The overall age-standardized incidence rates were 1.46/100,000 inhabitants in men and 0.9/100,000 inhabitants in women. Adenocarcinoma was the most common histological type (38%), followed by neuroendocrine tumors (35%), lymphoma (15%) and sarcoma (12%). Age at diagnosis and tumor location differed between adenocarcinoma and neuroendocrine tumors. The incidence of all four tumor types increased significantly over the 20-year period, with the exception of lymphoma in men. The annual percentage change for neuroendocrine tumors was 3.89% in men and 3.61% in women; for sarcoma, it was 3.38% and 4.08%, respectively. The incidence of adenocarcinoma and lymphoma also increased in women with an annual percentage change of 3.05% and 3.32%, respectively. CONCLUSION: Small bowel cancer incidence has increased over time. This increase occurred with different amplitudes and patterns in the four major histological types. The improvement in imaging techniques could partly explain this increase. It is necessary to determine whether predisposing conditions may contribute to this change.
BACKGROUND:Small bowel cancer is not a single entity. Population-based studies taking into account histological diversity are scarce. The aim of this study was to report on their trends in incidence by histology in France over the past 20 years. METHODS: All patients with a small bowel cancer diagnosed in 15 French administrative areas covered by a registry from the network of French cancer registries (FRANCIM) were included. Age-standardized incidence rates were estimated using the world standard population. Incidence rates were calculated by gender, age group, histology, and 5-year period. RESULTS: The overall age-standardized incidence rates were 1.46/100,000 inhabitants in men and 0.9/100,000 inhabitants in women. Adenocarcinoma was the most common histological type (38%), followed by neuroendocrine tumors (35%), lymphoma (15%) and sarcoma (12%). Age at diagnosis and tumor location differed between adenocarcinoma and neuroendocrine tumors. The incidence of all four tumor types increased significantly over the 20-year period, with the exception of lymphoma in men. The annual percentage change for neuroendocrine tumors was 3.89% in men and 3.61% in women; for sarcoma, it was 3.38% and 4.08%, respectively. The incidence of adenocarcinoma and lymphoma also increased in women with an annual percentage change of 3.05% and 3.32%, respectively. CONCLUSION:Small bowel cancer incidence has increased over time. This increase occurred with different amplitudes and patterns in the four major histological types. The improvement in imaging techniques could partly explain this increase. It is necessary to determine whether predisposing conditions may contribute to this change.
Entities:
Keywords:
Cancer registry; Histology; Incidence; Small bowel cancer; Trends
Authors: Vanessa Palascak-Juif; Anne Marie Bouvier; Jacques Cosnes; Bernard Flourié; Olivier Bouché; Guillaume Cadiot; Marc Lémann; Bruno Bonaz; Christine Denet; Philippe Marteau; Luc Gambiez; Laurent Beaugerie; Jean Faivre; Franck Carbonnel Journal: Inflamm Bowel Dis Date: 2005-09 Impact factor: 5.325
Authors: Karl Y Bilimoria; David J Bentrem; Jeffrey D Wayne; Clifford Y Ko; Charles L Bennett; Mark S Talamonti Journal: Ann Surg Date: 2009-01 Impact factor: 12.969