Literature DB >> 23478336

Hijacking nature--new approaches to unravel enzyme mechanisms and engineer improved biocatalysts.

Ivan Campeotto1, Carlos G Acevedo-Rocha.   

Abstract

The second EMBO conference on 'Catalytic Mechanisms by Biological Systems' took place in Groningen, the Netherlands, in October 2012. Structural, molecular and computational biologists, as well as chemists, biophysicists and engineers discussed technologies to improve our mechanistic understanding of enzymes, as well as the design of robust biocatalysts.

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Year:  2013        PMID： 23478336      PMCID： PMC3615656          DOI： 10.1038/embor.2013.26

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  10 in total

1.  Iterative approach to computational enzyme design.

Authors:  Heidi K Privett; Gert Kiss; Toni M Lee; Rebecca Blomberg; Roberto A Chica; Leonard M Thomas; Donald Hilvert; Kendall N Houk; Stephen L Mayo
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-22       Impact factor: 11.205

2.  Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.

Authors:  Olga Khersonsky; Gert Kiss; Daniela Röthlisberger; Orly Dym; Shira Albeck; Kendall N Houk; David Baker; Dan S Tawfik
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-08       Impact factor: 11.205

3.  An exciting but challenging road ahead for computational enzyme design.

Authors:  David Baker
Journal:  Protein Sci       Date:  2010-10       Impact factor: 6.725

Review 4.  Allosteric regulation and catalysis emerge via a common route.

Authors:  Nina M Goodey; Stephen J Benkovic
Journal:  Nat Chem Biol       Date:  2008-08       Impact factor: 15.040

5.  Synthetic biology: discovering new worlds and new words.

Authors:  Víctor de Lorenzo; Antoine Danchin
Journal:  EMBO Rep       Date:  2008-09       Impact factor: 8.807

Review 6.  Engineering the third wave of biocatalysis.

Authors:  U T Bornscheuer; G W Huisman; R J Kazlauskas; S Lutz; J C Moore; K Robins
Journal:  Nature       Date:  2012-05-09       Impact factor: 49.962

7.  Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization.

Authors:  Roberto Orru; Hanna M Dudek; Christian Martinoli; Daniel E Torres Pazmiño; Antoine Royant; Martin Weik; Marco W Fraaije; Andrea Mattevi
Journal:  J Biol Chem       Date:  2011-06-22       Impact factor: 5.157

8.  NMR structure of a lytic polysaccharide monooxygenase provides insight into copper binding, protein dynamics, and substrate interactions.

Authors:  Finn L Aachmann; Morten Sørlie; Gudmund Skjåk-Bræk; Vincent G H Eijsink; Gustav Vaaje-Kolstad
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-29       Impact factor: 11.205

9.  Long time scale GPU dynamics reveal the mechanism of drug resistance of the dual mutant I223R/H275Y neuraminidase from H1N1-2009 influenza virus.

Authors:  Christopher J Woods; Maturos Malaisree; Naruwan Pattarapongdilok; Pornthep Sompornpisut; Supot Hannongbua; Adrian J Mulholland
Journal:  Biochemistry       Date:  2012-05-17       Impact factor: 3.162

10.  Single-molecule paleoenzymology probes the chemistry of resurrected enzymes.

Authors:  Raul Perez-Jimenez; Alvaro Inglés-Prieto; Zi-Ming Zhao; Inmaculada Sanchez-Romero; Jorge Alegre-Cebollada; Pallav Kosuri; Sergi Garcia-Manyes; T Joseph Kappock; Masaru Tanokura; Arne Holmgren; Jose M Sanchez-Ruiz; Eric A Gaucher; Julio M Fernandez
Journal:  Nat Struct Mol Biol       Date:  2011-04-03       Impact factor: 15.369
  10 in total

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