Literature DB >> 2347584

A long-range restriction map between the alpha-globin complex and a marker closely linked to the polycystic kidney disease 1 (PKD1) locus.

P C Harris1, N J Barton, D R Higgs, S T Reeders, A O Wilkie.   

Abstract

Two polymorphic loci and two additional probes that map close to CMM65, which is tightly linked to the polycystic kidney disease 1 (PKD1) locus in chromosome band 16p13.3, are described. These new probes were isolated from a library that was enriched by preparative pulsed-field gel electrophoresis (PFGE) for sequences from a 320-kb NotI fragment that includes CMM65. Through the use of a panel of somatic cell hybrids and PFGE, the new polymorphic loci, PNL56S and NKISP1, were localized within 60 kb and approximately 250 kb distal to CMM65, respectively. A long-range restriction map linking these new probes and the distal markers EKMDA2, CMM103, and alpha-globin was constructed. These latter probes have been localized to regions approximately 900 kb, 1.2 Mb, and 1.9 Mb distal to CMM65, respectively. The entire region was found to be unusually rich in CpG dinucleotides. The new polymorphic probes and the long-range map will aid both the search for the PKD1 locus and the detailed characterization of this distal region of 16p.

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Year:  1990        PMID： 2347584     DOI： 10.1016/0888-7543(90)90541-2

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  13 in total

1.  PFGE MAPPER and PFGE READER: two tools to aid in the analysis and data input of pulse field gel electrophoresis maps.

Authors:  M A Shifman; P Nadkarni; P L Miller
Journal:  Proc Annu Symp Comput Appl Med Care       Date:  1992

2.  Molecular analysis of human chromosome 16 cosmid clones containing NotI sites.

Authors:  T Lerner; G Wright; B Leverone; W Dackowski; D Shook; M A Anderson; K Klinger; D Callen; G Landes
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Construction of a map of chromosome 16 by using radiation hybrids.

Authors:  I Ceccherini; G Romeo; S Lawrence; M H Breuning; P C Harris; H Himmelbauer; A M Frischauf; G R Sutherland; G G Germino; S T Reeders
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

4.  Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

Authors:  S A Liebhaber; E U Griese; I Weiss; F E Cash; H Ayyub; D R Higgs; J Horst
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

5.  Saturating the region of the polycystic kidney disease gene with NotI linking clones.

Authors:  H Himmelbauer; G G Germino; I Ceccherini; G Romeo; S T Reeders; A M Frischauf
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025

6.  Mapping around the Fused locus on mouse chromosome 17.

Authors:  H F Sutherland; E Pick; F Francis; H Lehrach; A M Frischauf
Journal:  Mamm Genome       Date:  1995-07       Impact factor: 2.957

7.  Characterization of three de novo derivative chromosomes 16 by "reverse chromosome painting" and molecular analysis.

Authors:  K A Rack; P C Harris; A B MacCarthy; R Boone; H Raynham; M McKinley; M Fitchett; C M Towe; P Rudd; J A Armour
Journal:  Am J Hum Genet       Date:  1993-05       Impact factor: 11.025

8.  Evidence of linkage disequilibrium in the Spanish polycystic kidney disease I population.

Authors:  B Peral; C J Ward; J L San Millán; S Thomas; R L Stallings; F Moreno; P C Harris
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

9.  Diagnosis of adult polycystic kidney disease by genetic markers and ultrasonographic imaging in a voluntary family register.

Authors:  R G Elles; K A Hodgkinson; N P Mallick; D J O'Donoghue; A P Read; S Rimmer; E A Watters; R Harris
Journal:  J Med Genet       Date:  1994-02       Impact factor: 6.318

10.  De novo truncation of chromosome 16p and healing with (TTAGGG)n in the alpha-thalassemia/mental retardation syndrome (ATR-16).

Authors:  J Lamb; P C Harris; A O Wilkie; W G Wood; J G Dauwerse; D R Higgs
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025
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