PURPOSE: This study assesses the perioperative course and long-term survival of inflammatory bowel disease (IBD)-associated vs. sporadic colorectal cancer (IBD-CRC vs. SCRC) after elimination of known confounders. METHODS: Between 1991 and 2007, n = 3,299 patients underwent surgery for CRC at our institution. Thirty-three IBD patients were identified and compared to 165 SCRC using a matched-pair analysis (1:5 scenario). As matching parameters were used: age, gender, Union Internationale Contre le Cancer (UICC) stage, site of primary lesion, and date of surgery. After univariate analysis of the perioperative course, a multivariate survival analysis (Cox) of all patients (n = 198) was performed. RESULTS: Significant differences were shown for preoperative symptoms (p = 0.022), transfusion rate (p = 0.01), ileostomy construction rate (p = 0.001), total complication rate (p = 0.042), and hospital stay (15 vs. 11 days, p < 0.001). Local tumor recurrence was three times higher in IBD-CRC (p = 0.004), and the 5-year survival rate was lower (49 % vs. 67 %, p = 0.03). IBD, advanced UICC stage, and synchronous liver metastasis were identified as independent prognostic factors. CONCLUSION: We demonstrate for the first time survival differences between IBD-CRC and SCRC after elimination of five known confounders. This might be caused by a difference in tumor biology resulting in a higher local recurrence rate in IBD-CRC.
PURPOSE: This study assesses the perioperative course and long-term survival of inflammatory bowel disease (IBD)-associated vs. sporadic colorectal cancer (IBD-CRC vs. SCRC) after elimination of known confounders. METHODS: Between 1991 and 2007, n = 3,299 patients underwent surgery for CRC at our institution. Thirty-three IBD patients were identified and compared to 165 SCRC using a matched-pair analysis (1:5 scenario). As matching parameters were used: age, gender, Union Internationale Contre le Cancer (UICC) stage, site of primary lesion, and date of surgery. After univariate analysis of the perioperative course, a multivariate survival analysis (Cox) of all patients (n = 198) was performed. RESULTS: Significant differences were shown for preoperative symptoms (p = 0.022), transfusion rate (p = 0.01), ileostomy construction rate (p = 0.001), total complication rate (p = 0.042), and hospital stay (15 vs. 11 days, p < 0.001). Local tumor recurrence was three times higher in IBD-CRC (p = 0.004), and the 5-year survival rate was lower (49 % vs. 67 %, p = 0.03). IBD, advanced UICC stage, and synchronous liver metastasis were identified as independent prognostic factors. CONCLUSION: We demonstrate for the first time survival differences between IBD-CRC and SCRC after elimination of five known confounders. This might be caused by a difference in tumor biology resulting in a higher local recurrence rate in IBD-CRC.
Authors: A Dignass; J C Preiss; D E Aust; F Autschbach; A Ballauff; G Barretton; B Bokemeyer; S Fichtner-Feigl; S Hagel; K R Herrlinger; G Jantschek; A Kroesen; W Kruis; T Kucharzik; J Langhorst; M Reinshagen; G Rogler; D Schleiermacher; C Schmidt; S Schreiber; H Schulze; E Stange; M Zeitz; J C Hoffmann; A Stallmach Journal: Z Gastroenterol Date: 2011-08-24 Impact factor: 2.000
Authors: T M Heimann; S C Oh; G Martinelli; A Szporn; N Luppescu; C A Lembo; R J Kurtz; T M Fasy; A J Greenstein Journal: Am J Surg Date: 1992-07 Impact factor: 2.565
Authors: Sabine Kersting; Matthias Bruewer; Mike G Laukoetter; Emile M Rijcken; Rudolf Mennigen; Horst Buerger; Norbert Senninger; Christian F Krieglstein Journal: Int J Colorectal Dis Date: 2006-07-18 Impact factor: 2.571
Authors: Axel Kleespies; Kathrin E Füessl; Hendrik Seeliger; Martin E Eichhorn; Mario H Müller; Markus Rentsch; Wolfgang E Thasler; Martin K Angele; Martin E Kreis; Karl-Walter Jauch Journal: Int J Colorectal Dis Date: 2009-06-03 Impact factor: 2.571
Authors: Thierry Delaunoit; Paul J Limburg; Richard M Goldberg; James F Lymp; Edward V Loftus Journal: Clin Gastroenterol Hepatol Date: 2006-03 Impact factor: 11.382
Authors: Ian S Reynolds; Aobhlinn O'Toole; Joseph Deasy; Deborah A McNamara; John P Burke Journal: Int J Colorectal Dis Date: 2017-01-11 Impact factor: 2.571
Authors: Florian Kuehn; Christina S Mullins; Mathias Krohn; Christine Harnack; Robert Ramer; Oliver H Krämer; Ernst Klar; Maja Huehns; Michael Linnebacher Journal: Sci Rep Date: 2016-04-18 Impact factor: 4.379
Authors: Mitchell Ramsey; Somashekar G Krishna; Peter P Stanich; Syed Husain; Edward J Levine; Darwin Conwell; Alice Hinton; Cheng Zhang Journal: Clin Transl Gastroenterol Date: 2017-11-30 Impact factor: 4.488
Authors: Yoon Dae Han; Mahdi Hussain Al Bandar; Audrius Dulskas; Min Soo Cho; Hyuk Hur; Byung Soh Min; Kang Young Lee; Nam Kyu Kim Journal: BMC Surg Date: 2017-03-21 Impact factor: 2.102
Authors: Francesco Vitali; Axel Wein; Timo Rath; Markus Eckstein; Clemens Neufert; Jürgen Siebler; Raja Atreya; Arndt Hartmann; Werner Hohenberger; Klaus Weber; Markus Friedrich Neurath; Robert Grützmann; Susanne Merkel Journal: Int J Colorectal Dis Date: 2021-12-04 Impact factor: 2.571