Literature DB >> 23474495

A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells.

Jing Xu1, Yang Lu, Songbo Qiu, Zhi-Nan Chen, Zhen Fan.   

Abstract

We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of α-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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Year:  2013        PMID： 23474495      PMCID： PMC3927232          DOI： 10.1016/j.canlet.2013.02.054

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  48 in total

1.  High incidence of EMMPRIN expression in human tumors.

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Journal:  Int J Cancer       Date:  2006-10-15       Impact factor: 7.396

2.  CD147, MMP-2, MMP-9 and MVD-CD34 are significant predictors of recurrence after liver transplantation in hepatocellular carcinoma patients.

Authors:  Qing Zhang; Xinguo Chen; Jun Zhou; Li Zhang; Qingchuan Zhao; Guangsheng Chen; Jing Xu; Feng Qian; Zhinan Chen
Journal:  Cancer Biol Ther       Date:  2006-07-30       Impact factor: 4.742

3.  HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma.

Authors:  Jing Xu; Hui-Yun Xu; Qing Zhang; Fei Song; Jian-Li Jiang; Xiang-Min Yang; Li Mi; Ning Wen; Rong Tian; Li Wang; Hui Yao; Qiang Feng; Yang Zhang; Jin-Liang Xing; Ping Zhu; Zhi-Nan Chen
Journal:  Mol Cancer Res       Date:  2007-06       Impact factor: 5.852

4.  Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component.

Authors:  Patrick E Corsino; Bradley J Davis; Peter H Nørgaard; Nicole N Teoh Parker; Mary Law; William Dunn; Brian K Law
Journal:  Neoplasia       Date:  2008-11       Impact factor: 5.715

5.  Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9.

Authors:  Wulf Sienel; Bernhard Polzer; Karimah Elshawi; Michael Lindner; Alicia Morresi-Hauf; Christian Vay; Fabian Eder; Bernward Passlick; Christoph A Klein
Journal:  Mod Pathol       Date:  2008-06-20       Impact factor: 7.842

6.  Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes.

Authors:  Nahed M Hawsawi; Hazem Ghebeh; Siti-Faujiah Hendrayani; Asma Tulbah; Maha Al-Eid; Taher Al-Tweigeri; Dahish Ajarim; Ayodele Alaiya; Said Dermime; Abdelilah Aboussekhra
Journal:  Cancer Res       Date:  2008-04-15       Impact factor: 12.701

7.  Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion.

Authors:  Xiao-Ling Yu; Tiancen Hu; Jia-Mu Du; Jian-Ping Ding; Xiang-Min Yang; Jian Zhang; Bin Yang; Xu Shen; Zheng Zhang; Wei-De Zhong; Ning Wen; Hualiang Jiang; Ping Zhu; Zhi-Nan Chen
Journal:  J Biol Chem       Date:  2008-04-22       Impact factor: 5.157

8.  PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.

Authors:  Yongping Crawford; Ian Kasman; Lanlan Yu; Cuiling Zhong; Xiumin Wu; Zora Modrusan; Josh Kaminker; Napoleone Ferrara
Journal:  Cancer Cell       Date:  2009-01-06       Impact factor: 31.743

9.  Involvement of CD147 in regulation of multidrug resistance to P-gp substrate drugs and in vitro invasion in breast cancer cells.

Authors:  Qing-Quan Li; Wen-Juan Wang; Jing-Da Xu; Xi-Xi Cao; Qi Chen; Jin-Ming Yang; Zu-De Xu
Journal:  Cancer Sci       Date:  2007-04-18       Impact factor: 6.716

10.  Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinoma.

Authors:  Qing Zhang; Jun Zhou; Xiao-Ming Ku; Xin-Guo Chen; Li Zhang; Jing Xu; Guang-Sheng Chen; Qin Li; Feng Qian; Rong Tian; Ning Wen; Zhi-Nan Chen
Journal:  Eur J Cancer Prev       Date:  2007-06       Impact factor: 2.497
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  17 in total

1.  The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1.

Authors:  Siti-Fauziah Hendrayani; Huda H Al-Khalaf; Abdelilah Aboussekhra
Journal:  J Biol Chem       Date:  2014-09-17       Impact factor: 5.157

2.  Esophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in Fibroblasts.

Authors:  Inga Kretschmer; Till Freudenberger; Sören Twarock; Yu Yamaguchi; Maria Grandoch; Jens W Fischer
Journal:  J Biol Chem       Date:  2015-12-23       Impact factor: 5.157

3.  A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication.

Authors:  Jason D Domogauer; Sonia M de Toledo; Edouard I Azzam
Journal:  J Vis Exp       Date:  2016-09-20       Impact factor: 1.355

4.  Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion.

Authors:  Bharat K R Chaganty; Songbo Qiu; Anneliese Gest; Yang Lu; Cristina Ivan; George A Calin; Louis M Weiner; Zhen Fan
Journal:  Cancer Lett       Date:  2018-05-08       Impact factor: 8.679

5.  Proteasome functioning in breast cancer: connection with clinical-pathological factors.

Authors:  Elena E Shashova; Yulia V Lyupina; Svetlana A Glushchenko; Elena M Slonimskaya; Olga V Savenkova; Alexey M Kulikov; Nikolay G Gornostaev; Irina V Kondakova; Natalia P Sharova
Journal:  PLoS One       Date:  2014-10-17       Impact factor: 3.240

Review 6.  Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment.

Authors:  María Belén Giorello; Francisco Raúl Borzone; Vivian Labovsky; Flavia Valeria Piccioni; Norma Alejandra Chasseing
Journal:  J Mammary Gland Biol Neoplasia       Date:  2021-01-04       Impact factor: 2.673

7.  Cancer associated fibroblasts and tumor growth: focus on multiple myeloma.

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Journal:  Cancers (Basel)       Date:  2014-06-27       Impact factor: 6.639

8.  Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts.

Authors:  Nadia A Hasaneen; Jian Cao; Ashleigh Pulkoski-Gross; Stanley Zucker; Hussein D Foda
Journal:  Respir Res       Date:  2016-02-17

9.  Expression of CD147 and matrix metalloproteinase-11 in colorectal cancer and their relationship to clinicopathological features.

Authors:  Xiuyun Tian; Chunxiang Ye; Yongyong Yang; Xiaoya Guan; Bin Dong; Min Zhao; Chunyi Hao
Journal:  J Transl Med       Date:  2015-10-27       Impact factor: 5.531

10.  High-throughput immunophenotypic characterization of bone marrow- and cord blood-derived mesenchymal stromal cells reveals common and differentially expressed markers: identification of angiotensin-converting enzyme (CD143) as a marker differentially expressed between adult and perinatal tissue sources.

Authors:  Eliana Amati; Omar Perbellini; Gianluca Rotta; Martina Bernardi; Katia Chieregato; Sabrina Sella; Francesco Rodeghiero; Marco Ruggeri; Giuseppe Astori
Journal:  Stem Cell Res Ther       Date:  2018-01-16       Impact factor: 6.832
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