OBJECTIVE: The purpose of the present study was to investigate the relationship between the Total Atherosclerotic Score (TAS), a measurement of the overall atherosclerotic burden of the arterial tree by whole body magnetic resonance angiography (WBMRA), and the risk of major adverse cardiovascular events (MACE), defined as cardiac death, myocardial infarction, stroke and/or coronary revascularization, assuming that TAS predicts MACE. METHODS AND RESULTS:305 randomly selected70 year-old subjects (47% women) underwentWBMRA. Their atherosclerotic burden was evaluated and TAS > 0, that is atherosclerotic changes, were found in 68% of subjects. During follow-up (mean 4.8 years), MACE occurred in 25 subjects (8.2%). Adjusting for multiple risk factors, TAS was associated with MACE (OR 8.86 for any degree of vessel lumen abnormality, 95%CI 1.14-69.11, p = 0.037). In addition, TAS improved discrimination and reclassification when added to the Framingham risk score (FRS), and ROC (Receiver Operator Curve) increased from 0.681 to 0.750 (p = 0.0421). CONCLUSION:In a population-based sample of 70 year old men and women WBMRA, with TAS, predicted MACE independently of major cardiovascular risk factors.
RCT Entities:
OBJECTIVE: The purpose of the present study was to investigate the relationship between the Total Atherosclerotic Score (TAS), a measurement of the overall atherosclerotic burden of the arterial tree by whole body magnetic resonance angiography (WBMRA), and the risk of major adverse cardiovascular events (MACE), defined as cardiac death, myocardial infarction, stroke and/or coronary revascularization, assuming that TAS predicts MACE. METHODS AND RESULTS: 305 randomly selected 70 year-old subjects (47% women) underwent WBMRA. Their atherosclerotic burden was evaluated and TAS > 0, that is atherosclerotic changes, were found in 68% of subjects. During follow-up (mean 4.8 years), MACE occurred in 25 subjects (8.2%). Adjusting for multiple risk factors, TAS was associated with MACE (OR 8.86 for any degree of vessel lumen abnormality, 95%CI 1.14-69.11, p = 0.037). In addition, TAS improved discrimination and reclassification when added to the Framingham risk score (FRS), and ROC (Receiver Operator Curve) increased from 0.681 to 0.750 (p = 0.0421). CONCLUSION: In a population-based sample of 70 year old men and women WBMRA, with TAS, predicted MACE independently of major cardiovascular risk factors.
Authors: Jonathan R Weir-McCall; Suzanne L Duce; Stephen J Gandy; Shona Z Matthew; Patricia Martin; Deirdre B Cassidy; Lynne McCormick; Jill J F Belch; Allan D Struthers; Helen M Colhoun; J Graeme Houston Journal: BMC Med Imaging Date: 2016-02-29 Impact factor: 1.930
Authors: S J Gandy; M Lambert; J J F Belch; I D Cavin; E Crowe; R Littleford; J A Macfarlane; S Z Matthew; P Martin; R S Nicholas; A D Struthers; F Sullivan; S A Waugh; R D White; J R Weir-McCall; J G Houston Journal: Clin Radiol Date: 2015-03-16 Impact factor: 2.350
Authors: Jonathan R Weir-McCall; Deirdre B Cassidy; Jill J F Belch; Stephen J Gandy; J G Houston; Matthew A Lambert; Roberta C Littleford; Janice Rowland; Allan D Struthers; Faisel Khan Journal: Br J Radiol Date: 2016-06-28 Impact factor: 3.039
Authors: Matthew A Lambert; Jonathan R Weir-McCall; Marco Salsano; Stephen J Gandy; Daniel Levin; Ian Cavin; Roberta Littleford; Jennifer A MacFarlane; Shona Z Matthew; Richard S Nicholas; Allan D Struthers; Frank Sullivan; Shelley A Henderson; Richard D White; Jill J F Belch; J Graeme Houston Journal: Radiology Date: 2018-05-01 Impact factor: 29.146
Authors: Suzanne L Duce; Jonathan R Weir-McCall; Stephen J Gandy; Shona Z Matthew; Deirdre B Cassidy; Lynne McCormick; Petra Rauchhaus; Helen Looker; Helen M Colhoun; J Graeme Houston Journal: Cardiovasc Diabetol Date: 2015-09-18 Impact factor: 9.951
Authors: Jonathan R Weir-McCall; Faisel Khan; Matthew A Lambert; Carly L Adamson; Michael Gardner; Stephen J Gandy; Prasad Guntur Ramkumar; Jill J F Belch; Allan D Struthers; Petra Rauchhaus; Andrew D Morris; J Graeme Houston Journal: PLoS One Date: 2014-06-16 Impact factor: 3.240
Authors: Jonathan R Weir-McCall; Richard D White; Prasad G Ramkumar; Stephen J Gandy; Faisel Khan; Jill J F Belch; Allan D Struthers; J Graeme Houston Journal: Int J Cardiovasc Imaging Date: 2016-01-25 Impact factor: 2.357
Authors: Jonathan R Weir-McCall; Matthew Lambert; Stephen J Gandy; Jill J F Belch; Ian Cavin; Shelley A Henderson; Roberta Littleford; Jennifer A Macfarlane; Shona Z Matthew; R Stephen Nicholas; Allan D Struthers; Frank Sullivan; Richard D White; J Graeme Houston Journal: J Cardiovasc Magn Reson Date: 2018-01-30 Impact factor: 5.364