PURPOSE: To intraindividually compare the delineation of intracranial arterial vasculature in nonenhanced versus contrast-enhanced magnetization prepared rapid gradient echo (MPRAGE) imaging at 7 Tesla (T). MATERIALS AND METHODS: Sixteen subjects were examined on a 7 T whole-body magnetic resonance system (Magnetom 7T) equipped with a 32-channel transmit/receive head coil. MPRAGE imaging was performed pre- and postcontrast after the application of 0.1 mmol/kg bodyweight gadobutrol. For qualitative analysis, the delineation of the intracranial arteries, overall image quality, and image impairment were assessed in the nonenhanced and contrast-enhanced datasets using a 5-point scale (5 = excellent to 1 = nondiagnostic). Additionally, contrast ratios (CR) of the middle cerebral artery in correlation to surrounding gray matter in nonenhanced and postcontrast images were obtained. For statistical analysis a Wilcoxon signed-rank test was applied. RESULTS: Nonenhanced MPRAGE imaging offered an excellent delineation of the central vessel segments of the anterior circulation (mean anterior circulation 4.6) and a moderate- to high-quality assessment of the vessels of the posterior circulation (mean posterior circulation 3.9). Vessel delineation was improved in all assessed segments in the contrast-enhanced datasets, except for the cavernous segment of the internal carotid artery. Quantitative analysis revealed a mild, nonsignificant increase in CR mean values of the M1 segment (CRnonenhanced 0.67; CRcontrast-enhanced 0.69). CONCLUSION: Our results demonstrate the high diagnostic value of nonenhanced 7 T MPRAGE imaging for the assessment of the intracranial arterial vasculature, with improved assessment of the peripheral segments because of the application of a contrast agent.
PURPOSE: To intraindividually compare the delineation of intracranial arterial vasculature in nonenhanced versus contrast-enhanced magnetization prepared rapid gradient echo (MPRAGE) imaging at 7 Tesla (T). MATERIALS AND METHODS: Sixteen subjects were examined on a 7 T whole-body magnetic resonance system (Magnetom 7T) equipped with a 32-channel transmit/receive head coil. MPRAGE imaging was performed pre- and postcontrast after the application of 0.1 mmol/kg bodyweight gadobutrol. For qualitative analysis, the delineation of the intracranial arteries, overall image quality, and image impairment were assessed in the nonenhanced and contrast-enhanced datasets using a 5-point scale (5 = excellent to 1 = nondiagnostic). Additionally, contrast ratios (CR) of the middle cerebral artery in correlation to surrounding gray matter in nonenhanced and postcontrast images were obtained. For statistical analysis a Wilcoxon signed-rank test was applied. RESULTS: Nonenhanced MPRAGE imaging offered an excellent delineation of the central vessel segments of the anterior circulation (mean anterior circulation 4.6) and a moderate- to high-quality assessment of the vessels of the posterior circulation (mean posterior circulation 3.9). Vessel delineation was improved in all assessed segments in the contrast-enhanced datasets, except for the cavernous segment of the internal carotid artery. Quantitative analysis revealed a mild, nonsignificant increase in CR mean values of the M1 segment (CRnonenhanced 0.67; CRcontrast-enhanced 0.69). CONCLUSION: Our results demonstrate the high diagnostic value of nonenhanced 7 T MPRAGE imaging for the assessment of the intracranial arterial vasculature, with improved assessment of the peripheral segments because of the application of a contrast agent.
Authors: T Matsushige; M Kraemer; T Sato; P Berlit; M Forsting; M E Ladd; R Jabbarli; U Sure; N Khan; M Schlamann; K H Wrede Journal: AJNR Am J Neuroradiol Date: 2018-06-07 Impact factor: 3.825
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Authors: T Sato; T Matsushige; B Chen; O Gembruch; P Dammann; R Jabbarli; M Forsting; A Junker; S Maderwald; H H Quick; M E Ladd; U Sure; K H Wrede Journal: AJNR Am J Neuroradiol Date: 2019-05-30 Impact factor: 3.825
Authors: J Kuchling; T Sinnecker; I Bozin; J Dörr; V I Madai; J Sobesky; T Niendorf; F Paul; J Wuerfel Journal: Nervenarzt Date: 2014-04 Impact factor: 1.214
Authors: Karsten H Wrede; Toshinori Matsushige; Sophia L Goericke; Bixia Chen; Lale Umutlu; Harald H Quick; Mark E Ladd; Sören Johst; Michael Forsting; Ulrich Sure; Marc Schlamann Journal: Eur Radiol Date: 2016-03-18 Impact factor: 5.315
Authors: Karsten H Wrede; Philipp Dammann; Christoph Mönninghoff; Sören Johst; Stefan Maderwald; I Erol Sandalcioglu; Oliver Müller; Neriman Özkan; Mark E Ladd; Michael Forsting; Marc U Schlamann; Ulrich Sure; Lale Umutlu Journal: PLoS One Date: 2014-01-06 Impact factor: 3.240
Authors: Anja Fischer; Oliver Kraff; Stefan Maderwald; Karsten Beiderwellen; Mark E Ladd; Michael Forsting; Thomas C Lauenstein; Lale Umutlu Journal: PLoS One Date: 2014-06-02 Impact factor: 3.240