Literature DB >> 23473373

Multifunctional nanoparticles based on a single-molecule modification for the treatment of drug-resistant cancer.

Dun Wang1, Jingling Tang, Yongjun Wang, Srinivas Ramishetti, Qiang Fu, Kelly Racette, Feng Liu.   

Abstract

Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively explored for the treatment of MDR in cancer because of its ability to inhibit P-glycoprotein. Here, we have established multifunctional nanoparticles (MFNPs) using a single-molecule modification of TPGS, which can deliver a hydrophobic drug, paclitaxel (PTX), and a hydrophilic drug, fluorouracil (5-FU), and overcome MDR in cancer. Our data indicated that, when delivered into a PTX-resistant cell line using MFNPs, the combination of PTX and 5-FU was more cytotoxic than each agent individually.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23473373      PMCID： PMC3685192          DOI： 10.1021/mp400022h

Source DB:  PubMed          Journal:  Mol Pharm        ISSN： 1543-8384            Impact factor:   4.939


  16 in total

1.  Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.

Authors:  Juntao Luo; Kai Xiao; Yuanpei Li; Joyce S Lee; Lifang Shi; Yih-Horng Tan; Li Xing; R Holland Cheng; Gang-Yu Liu; Kit S Lam
Journal:  Bioconjug Chem       Date:  2010-07-21       Impact factor: 4.774

2.  A facile method for synthesis of N-acyloxymethyl-5-fluorouracils, as a class of antitumor agents.

Authors:  S Ahmad; S Ozaki; T Nagase; M Iigo; R Tokuzen; A Hoshi
Journal:  Chem Pharm Bull (Tokyo)       Date:  1987-10       Impact factor: 1.645

3.  P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone].

Authors:  Fuminori Teraishi; Shuhong Wu; Jiichiro Sasaki; Lidong Zhang; Hong-Bo Zhu; John J Davis; Bingliang Fang
Journal:  J Pharmacol Exp Ther       Date:  2005-04-14       Impact factor: 4.030

4.  Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS).

Authors:  J M Dintaman; J A Silverman
Journal:  Pharm Res       Date:  1999-10       Impact factor: 4.200

5.  Targeted cancer therapy with novel high drug-loading nanocrystals.

Authors:  Feng Liu; Ji-Young Park; Yong Zhang; Christine Conwell; Yang Liu; Surendar Reddy Bathula; Leaf Huang
Journal:  J Pharm Sci       Date:  2010-08       Impact factor: 3.534

Review 6.  The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR).

Authors:  E Teodori; S Dei; C Martelli; S Scapecchi; F Gualtieri
Journal:  Curr Drug Targets       Date:  2006-07       Impact factor: 3.465

7.  p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest.

Authors:  Christian J Braun; Xin Zhang; Irina Savelyeva; Sonja Wolff; Ute M Moll; Troels Schepeler; Torben F Ørntoft; Claus L Andersen; Matthias Dobbelstein
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

Review 8.  Multi-functional nanocarriers to overcome tumor drug resistance.

Authors:  Lara S Jabr-Milane; Lilian E van Vlerken; Sunita Yadav; Mansoor M Amiji
Journal:  Cancer Treat Rev       Date:  2008-06-05       Impact factor: 12.111

9.  Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS.

Authors:  Michael F Wempe; Charles Wright; James L Little; Janet W Lightner; Shannon E Large; George B Caflisch; Charles M Buchanan; Peter J Rice; Vincent J Wacher; Karen M Ruble; Kevin J Edgar
Journal:  Int J Pharm       Date:  2008-11-30       Impact factor: 5.875

Review 10.  [Mechanisms of multidrug resistance in tumor cells and analytical methods for its detection].

Authors:  Y Takemura; H Kobayashi; H Miyachi
Journal:  Rinsho Byori       Date:  1998-08
View more
  8 in total

Review 1.  Nanomedicine therapeutic approaches to overcome cancer drug resistance.

Authors:  Janet L Markman; Arthur Rekechenetskiy; Eggehard Holler; Julia Y Ljubimova
Journal:  Adv Drug Deliv Rev       Date:  2013-10-10       Impact factor: 15.470

2.  Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein-mediated multidrug resistance.

Authors:  Aniruddha Roy; Mami Murakami; Mark J Ernsting; Bryan Hoang; Elijus Undzys; Shyh-Dar Li
Journal:  Mol Pharm       Date:  2014-03-06       Impact factor: 4.939

Review 3.  Recent developments in d-α-tocopheryl polyethylene glycol-succinate-based nanomedicine for cancer therapy.

Authors:  Songwei Tan; Chenming Zou; Wei Zhang; Mingxing Yin; Xueqin Gao; Qing Tang
Journal:  Drug Deliv       Date:  2017-11       Impact factor: 6.419

4.  Combinational delivery of hydrophobic and hydrophilic anticancer drugs in single nanoemulsions to treat MDR in cancer.

Authors:  Yan Ma; Dan Liu; Dun Wang; Yongjun Wang; Qiang Fu; John K Fallon; Xinggang Yang; Zhonggui He; Feng Liu
Journal:  Mol Pharm       Date:  2014-04-21       Impact factor: 4.939

5.  Shape-controlled paclitaxel nanoparticles with multiple morphologies: rod-shaped, worm-like, spherical, and fingerprint-like.

Authors:  Yongjun Wang; Dun Wang; Qiang Fu; Dan Liu; Yan Ma; Kelly Racette; Zhonggui He; Feng Liu
Journal:  Mol Pharm       Date:  2014-09-08       Impact factor: 4.939

Review 6.  Recent Advances in the Application of Vitamin E TPGS for Drug Delivery.

Authors:  Conglian Yang; Tingting Wu; Yan Qi; Zhiping Zhang
Journal:  Theranostics       Date:  2018-01-01       Impact factor: 11.556

7.  Nanotechnological approaches for counteracting multidrug resistance in cancer.

Authors:  Chiara Martinelli; Marco Biglietti
Journal:  Cancer Drug Resist       Date:  2020-10-12

Review 8.  Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer.

Authors:  Mohamed Haider; Amr Elsherbeny; Valeria Pittalà; Valeria Consoli; Maha Ali Alghamdi; Zahid Hussain; Ghalia Khoder; Khaled Greish
Journal:  Int J Mol Sci       Date:  2022-02-06       Impact factor: 5.923
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.