Literature DB >> 23473026

Metformin-acting through cyclic AMP as well as AMP?

D Grahame Hardie1.   

Abstract

Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23473026     DOI： 10.1016/j.cmet.2013.02.011

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  4 in total

1.  Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes.

Authors:  José Thalles Lacerda; Patrícia R L Gomes; Giovanna Zanetti; Nathana Mezzalira; Otoniel G Lima; Leonardo V M de Assis; Ali Guler; Ana Maria Castrucci; Maria Nathália Moraes
Journal:  Int J Mol Sci       Date:  2022-06-24       Impact factor: 6.208

Review 2.  The Mechanism of Action of Biguanides: New Answers to a Complex Question.

Authors:  Laura Di Magno; Fiorella Di Pastena; Rosa Bordone; Sonia Coni; Gianluca Canettieri
Journal:  Cancers (Basel)       Date:  2022-06-30       Impact factor: 6.575

3.  Hepatic Glucose Output Inhibition by Mexican Plants Used in the Treatment of Type 2 Diabetes.

Authors:  Gerardo Mata-Torres; Adolfo Andrade-Cetto; Fernanda Artemisa Espinoza-Hernández; René Cárdenas-Vázquez
Journal:  Front Pharmacol       Date:  2020-03-03       Impact factor: 5.810

Review 4.  Exercise in a Pill: The Latest on Exercise-Mimetics.

Authors:  Davide Guerrieri; Hyo Youl Moon; Henriette van Praag
Journal:  Brain Plast       Date:  2017-03-28
  4 in total

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