BACKGROUND: Black rice is rich in anthocyanins, especially cyanidin-3-glucoside (C3G). This study examined the effects of a C3G-rich extract from black rice on hyperlipidaemia induced by a high fat/cholesterol diet (HFCD) in rats. RESULTS: Male Sprague-Dawley rats were fed either HFCD or HFCD containing 150 mg kg⁻¹ body weight C3G (HFCD+C3G) for 4 weeks. We found that C3G significantly decreased serum levels of total cholesterol, free cholesterol, triglycerides, and free fatty acids in rats fed a HFCD. Similarly, hepatic cholesterol and triglyceride levels and the activities of hepatic lipogenic enzymes (malic enzyme and glucose-6-phosphate dehydrogenase) were significantly reduced by C3G supplementation. CONCLUSION: These results suggest that C3G can ameliorate HFCD-induced hyperlipidaemia in part by modulating the activities of hepatic lipogenic enzymes.
BACKGROUND: Black rice is rich in anthocyanins, especially cyanidin-3-glucoside (C3G). This study examined the effects of a C3G-rich extract from black rice on hyperlipidaemia induced by a high fat/cholesterol diet (HFCD) in rats. RESULTS: Male Sprague-Dawley rats were fed either HFCD or HFCD containing 150 mg kg⁻¹ body weight C3G (HFCD+C3G) for 4 weeks. We found that C3G significantly decreased serum levels of total cholesterol, freecholesterol, triglycerides, and free fatty acids in rats fed a HFCD. Similarly, hepatic cholesterol and triglyceride levels and the activities of hepatic lipogenic enzymes (malic enzyme and glucose-6-phosphate dehydrogenase) were significantly reduced by C3G supplementation. CONCLUSION: These results suggest that C3G can ameliorate HFCD-induced hyperlipidaemia in part by modulating the activities of hepatic lipogenic enzymes.
Authors: Mattia Garutti; Gerardo Nevola; Roberta Mazzeo; Linda Cucciniello; Fabiana Totaro; Carlos Alejandro Bertuzzi; Riccardo Caccialanza; Paolo Pedrazzoli; Fabio Puglisi Journal: Front Nutr Date: 2022-05-25
Authors: Habibul Bari Shozib; Md Mariful Islam; Sultan Abu Saleh Mahmud; Md Nazmul Bari; Nasima Akter; Saima Jahan; Shakir Hosen; Mohammad Nazir Hossain; A H M Nurun Nabi; Muhammad Ali Siddiquee; Md Manjurul Haque Journal: Saudi J Biol Sci Date: 2021-08-23 Impact factor: 4.219
Authors: Bohkyung Kim; Sang Gil Lee; Young-Ki Park; Chai Siah Ku; Tho X Pham; Casey J Wegner; Yue Yang; Sung I Koo; Ock K Chun; Ji-Young Lee Journal: Nutr Res Pract Date: 2016-07-29 Impact factor: 1.926