| Literature DB >> 23462211 |
Neerja Tiwari1, Jayprakash Thakur, Dharmendra Saikia, Madan M Gupta.
Abstract
A new halimane diterpenoid, 13-hydroxy-5(10),14-halimadien-6-one (1) and two new labdane diterpenoids, 6α,7α-diacetoxy-13-hydroxy-8(9),14-labdadien (2) and 9-hydroxy-13(14)-labden-15,16-olide (3), were isolated for the first time, along with fifteen known compounds, from the hexane soluble fraction of methanolic extract of Vitex trifolia leaves. The structures of these new diterpenoids were elucidated by spectral analysis. Their relative configurations were established using analysis of NOESY correlations and coupling constants observed in (1)H NMR. Compounds 2, 3 and another known diterpenoid, isoambreinolide (4) were evaluated for antitubercular activity. 3 and 4 exhibited antitubercular activity (MIC=100 and 25 μg/ml) against Mycobacterium tuberculosis H37Rv in BACTEC-460 assay.Entities:
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Year: 2013 PMID： 23462211 DOI： 10.1016/j.phymed.2013.01.003
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340